Ari Melnick

Research interests

Publications

• The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

  Blood · 2022 · https://doi.org/10.1182/blood.2022015851

• Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

  Cancer Discovery · 2019 · 10.1158/2159-8290.cd-18-1090

• The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

  Science · 2019 · https://doi.org/10.1126/science.aau8650

• ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.02.002

• The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

  Nature Medicine · 2017 · 10.1038/nm.4416

• Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

  Nature Medicine · 2016 · 10.1038/nm.4125

• The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

  Nature Medicine · 2015 · 10.1038/nm.3943

• Loss of BAP1 function leads to EZH2-dependent transformation

  Nature Medicine · 2015 · 10.1038/nm.3947

• DNMT1-interacting RNAs block gene-specific DNA methylation

  Nature · 2013 · 10.1038/nature12598

• EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

  Cancer Cell · 2013 · https://doi.org/10.1016/j.ccr.2013.04.011

• A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

  Cell · 2012 · 10.1016/j.cell.2012.11.039

• methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

  Genome biology · 2012 · https://doi.org/10.1186/gb-2012-13-10-r87

• Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

  Nature Genetics · 2012 · 10.1038/ng.2413

• ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression

  Cancer Cell · 2012 · 10.1016/j.ccr.2012.06.032

• IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

  Nature · 2012 · 10.1038/nature11323

• IDH mutation impairs histone demethylation and results in a block to cell differentiation

  Nature · 2012 · https://doi.org/10.1038/nature10860

• Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1112304

• Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

  Cancer Cell · 2011 · 10.1016/j.ccr.2011.06.001

• DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

  Cancer Cell · 2010 · 10.1016/j.ccr.2009.11.020

• Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

  Nature Biotechnology · 2010 · 10.1038/nbt.1667

• Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

  Cancer Cell · 2010 · https://doi.org/10.1016/j.ccr.2010.11.015

• Outcome of Deferred Initial Therapy in Mantle-Cell Lymphoma

  Journal of Clinical Oncology · 2009 · 10.1200/jco.2008.19.6121

• MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

  Blood · 2009 · 10.1182/blood-2009-01-200519

• Comparative isoschizomer profiling of cytosine methylation: The HELP assay

  Genome Research · 2006 · 10.1101/gr.5273806

• Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

  Blood · 1999 · 10.1182/blood.v93.10.3167.410k44_3167_3215

Current projects

No projects listed.