James C. Yang

Research interests

Publications

• Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers

  Science · 2022 · https://doi.org/10.1126/science.abl5447

• CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-11869-4

• Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor–transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma

  Journal of Immunotherapy · 2019 · https://doi.org/10.1097/cji.0000000000000260

• Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2016.71.3024

• Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma

  Clinical Cancer Research · 2015 · https://doi.org/10.1158/1078-0432.ccr-14-2085

• Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor

  Journal of Clinical Oncology · 2014 · https://doi.org/10.1200/jco.2014.56.2025

• Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

  Clinical Cancer Research · 2014 · https://doi.org/10.1158/1078-0432.ccr-14-0433

• Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

  Science · 2014 · https://doi.org/10.1126/science.1251102

• Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

  Journal of Clinical Oncology · 2011 · https://doi.org/10.1200/jco.2010.32.2537

• B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells

  Blood · 2011 · https://doi.org/10.1182/blood-2011-10-384388

• CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma

  Clinical Cancer Research · 2010 · https://doi.org/10.1158/1078-0432.ccr-10-1297

• Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

  Molecular Therapy · 2010 · https://doi.org/10.1038/mt.2010.24

• Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma

  Journal of Immunotherapy · 2010 · https://doi.org/10.1097/cji.0b013e3181eec14c

• T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

  Molecular Therapy · 2010 · https://doi.org/10.1038/mt.2010.272

• Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

  Blood · 2009 · https://doi.org/10.1182/blood-2009-03-211714

• Adoptive cell transfer: a clinical path to effective cancer immunotherapy

  Nature reviews. Cancer · 2008 · https://doi.org/10.1038/nrc2355

• A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer

  Clinical Cancer Research · 2006 · https://doi.org/10.1158/1078-0432.ccr-06-1183

• Immune recognition of a human renal cancer antigen through post-translational protein splicing

  Nature · 2004 · https://doi.org/10.1038/nature02240

• Cancer immunotherapy: moving beyond current vaccines

  Nature Medicine · 2004 · https://doi.org/10.1038/nm1100

• Phase I Study of the Intravenous Administration of AttenuatedSalmonella typhimuriumto Patients With Metastatic Melanoma

  Journal of Clinical Oncology · 2002 · https://doi.org/10.1200/jco.2002.20.1.142

• A Phase I Study of Nonmyeloablative Chemotherapy and Adoptive Transfer of Autologous Tumor Antigen-Specific T Lymphocytes in Patients With Metastatic Melanoma

  Journal of Immunotherapy · 2002 · https://doi.org/10.1097/00002371-200205000-00007

• Adoptive Transfer of Cloned Melanoma-Reactive T Lymphocytes for the Treatment of Patients with Metastatic Melanoma

  Journal of Immunotherapy · 2001 · https://doi.org/10.1097/00002371-200107000-00012

• High Avidity CTLs for Two Self-Antigens Demonstrate Superior In Vitro and In Vivo Antitumor Efficacy

  The Journal of Immunology · 1999 · https://doi.org/10.4049/jimmunol.162.2.989

• Gene Transfer into Humans — Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction

  New England Journal of Medicine · 1990 · https://doi.org/10.1056/nejm199008303230904

Current projects

No projects listed.