Carl‐Henrik Heldin

Research interests

Publications

• Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

  Journal of Clinical Investigation · 2004 · https://doi.org/10.1172/jci19189

• High interstitial fluid pressure — an obstacle in cancer therapy

  Nature reviews. Cancer · 2004 · https://doi.org/10.1038/nrc1456

• Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.m208258200

• Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

  Molecular Biology of the Cell · 2003 · https://doi.org/10.1091/mbc.02-03-0037

• Control of Smad7 Stability by Competition between Acetylation and Ubiquitination

  Molecular Cell · 2002 · https://doi.org/10.1016/s1097-2765(02)00639-1

• TGF-β signaling by Smad proteins

  Advances in immunology · 2000 · https://doi.org/10.1016/s0065-2776(00)75003-6

• Signaling inputs converge on nuclear effectors in TGF-β signaling

  Trends in Biochemical Sciences · 2000 · https://doi.org/10.1016/s0968-0004(99)01519-4

• Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

  Physiological Reviews · 1999 · https://doi.org/10.1152/physrev.1999.79.4.1283

• TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells

  Journal of Cell Science · 1999 · https://doi.org/10.1242/jcs.112.24.4557

• Specificity, diversity, and regulation in TGF‐β superfamily signaling

  The FASEB Journal · 1999 · https://doi.org/10.1096/fasebj.13.15.2105

• Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

  Journal of Biological Chemistry · 1998 · https://doi.org/10.1074/jbc.273.33.21145

• Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7

  Journal of Biological Chemistry · 1998 · https://doi.org/10.1074/jbc.273.44.29195

• The L45 loop in type I receptors for TGF‐β family members is a critical determinant in specifying Smad isoform activation

  FEBS Letters · 1998 · https://doi.org/10.1016/s0014-5793(98)00954-5

• Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members

  Biochemical and Biophysical Research Communications · 1998 · https://doi.org/10.1006/bbrc.1998.9170

• Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

  Journal of Biological Chemistry · 1997 · https://doi.org/10.1074/jbc.272.44.28107

• Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

  Nature · 1997 · https://doi.org/10.1038/39369

• Bone morphogenetic protein receptors

  Bone · 1996 · https://doi.org/10.1016/s8756-3282(96)00259-1

• Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

  Current Opinion in Cell Biology · 1996 · https://doi.org/10.1016/s0955-0674(96)80058-5

• Dimerization of cell surface receptors in signal transduction

  Cell · 1995 · https://doi.org/10.1016/0092-8674(95)90404-2

• Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

  The Journal of Cell Biology · 1995 · https://doi.org/10.1083/jcb.130.1.217

• Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

  Proceedings of the National Academy of Sciences · 1995 · https://doi.org/10.1073/pnas.92.17.7632

• Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

  Journal of Biological Chemistry · 1994 · https://doi.org/10.1016/s0021-9258(18)47116-5

• Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

  Journal of Biological Chemistry · 1994 · https://doi.org/10.1016/s0021-9258(17)32506-1

• Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

  Science · 1994 · https://doi.org/10.1126/science.8140412

• Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

  Journal of Biological Chemistry · 1994 · https://doi.org/10.1016/s0021-9258(17)32142-7

• Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

  PubMed · 1993

• PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage

  Development · 1989 · https://doi.org/10.1242/dev.105.3.595

Current projects

No projects listed.