Mats O. Karlsson

Research interests

Publications

• A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

  The Lancet · 2023 · https://doi.org/10.1016/s0140-6736(22)01841-4

• An automated sampling importance resampling procedure for estimating parameter uncertainty

  Journal of Pharmacokinetics and Pharmacodynamics · 2017 · https://doi.org/10.1007/s10928-017-9542-0

• Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics

  CPT Pharmacometrics & Systems Pharmacology · 2016 · https://doi.org/10.1002/psp4.12161

• Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resampling

  Journal of Pharmacokinetics and Pharmacodynamics · 2016 · https://doi.org/10.1007/s10928-016-9487-8

• Integrated Population Pharmacokinetic Analysis of Voriconazole in Children, Adolescents, and Adults

  Antimicrobial Agents and Chemotherapy · 2012 · https://doi.org/10.1128/aac.05761-11

• Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

  The AAPS Journal · 2011 · https://doi.org/10.1208/s12248-011-9255-z

• Handling Data Below the Limit of Quantification in Mixed Effect Models

  The AAPS Journal · 2009 · https://doi.org/10.1208/s12248-009-9112-5

• Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics: Problems and Solutions

  The AAPS Journal · 2009 · https://doi.org/10.1208/s12248-009-9133-0

• Likelihood based approaches to handling data below the quantification limit using NONMEM VI

  Journal of Pharmacokinetics and Pharmacodynamics · 2008 · https://doi.org/10.1007/s10928-008-9094-4

• Population Pharmacokinetic Analysis of Voriconazole Plasma Concentration Data from Pediatric Studies

  Antimicrobial Agents and Chemotherapy · 2008 · https://doi.org/10.1128/aac.00751-08

• Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies

  Journal of Pharmacokinetics and Pharmacodynamics · 2007 · https://doi.org/10.1007/s10928-007-9066-0

• Conditional Weighted Residuals (CWRES): A Model Diagnostic for the FOCE Method

  Pharmaceutical Research · 2007 · https://doi.org/10.1007/s11095-007-9361-x

• Diagnosing Model Diagnostics

  Clinical Pharmacology & Therapeutics · 2007 · https://doi.org/10.1038/sj.clpt.6100241

• Semimechanistic Pharmacokinetic/Pharmacodynamic Model for Assessment of Activity of Antibacterial Agents from Time-Kill Curve Experiments

  Antimicrobial Agents and Chemotherapy · 2006 · https://doi.org/10.1128/aac.00604-06

• Association ofCYP2C8, CYP3A4, CYP3A5, andABCB1Polymorphisms with the Pharmacokinetics of Paclitaxel

  Clinical Cancer Research · 2005 · https://doi.org/10.1158/1078-0432.ccr-05-1152

• Pharmacokinetics and Safety of Intravenous Voriconazole in Children after Single- or Multiple-Dose Administration

  Antimicrobial Agents and Chemotherapy · 2004 · https://doi.org/10.1128/aac.48.6.2166-2172.2004

• Irinotecan pathway genotype analysis to predict pharmacokinetics.

  PubMed · 2003

• Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis

  AAPS PharmSci · 2002 · https://doi.org/10.1208/ps040427

• Model of Chemotherapy-Induced Myelosuppression With Parameter Consistency Across Drugs

  Journal of Clinical Oncology · 2002 · https://doi.org/10.1200/jco.2002.02.140

• Mechanism-Based Pharmacokinetic Model for Paclitaxel

  Journal of Clinical Oncology · 2001 · https://doi.org/10.1200/jco.2001.19.20.4065

• Assessment of Actual Significance Levels for Covariate Effects in NONMEM

  Journal of Pharmacokinetics and Pharmacodynamics · 2001 · https://doi.org/10.1023/a:1011527125570

• Automated Covariate Model Building Within NONMEM

  Pharmaceutical Research · 1998 · https://doi.org/10.1023/a:1011970125687

• Xpose—an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM

  Computer Methods and Programs in Biomedicine · 1998 · https://doi.org/10.1016/s0169-2607(98)00067-4

• The importance of modeling interoccasion variability in population pharmacokinetic analyses

  Journal of Pharmacokinetics and Biopharmaceutics · 1993 · https://doi.org/10.1007/bf01113502

Current projects

No projects listed.