Bon‐Kyoung Koo

Research interests

Publications

• Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

  Cell stem cell · 2020 · 10.1016/j.stem.2020.06.020

• Human organoids: model systems for human biology and medicine

  Nature Reviews Molecular Cell Biology · 2020 · https://doi.org/10.1038/s41580-020-0259-3

• Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

  Cell · 2018 · 10.1016/j.cell.2018.07.027

• Human gastric cancer modelling using organoids

  Gut · 2018 · 10.1136/gutjnl-2017-314549

• DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

  Gut · 2017 · 10.1136/gutjnl-2017-314817

• Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

  Nature Cell Biology · 2017 · https://doi.org/10.1038/ncb3516

• Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

  Nature Medicine · 2017 · https://doi.org/10.1038/nm.4438

• DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome

  Gastroenterology · 2017 · 10.1053/j.gastro.2017.10.007

• Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

  Nature Protocols · 2016 · 10.1038/nprot.2016.097

• Modeling mouse and human development using organoid cultures

  Development · 2015 · 10.1242/dev.118570

• Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

  Cell stem cell · 2015 · 10.1016/j.stem.2014.12.006

• Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

  Cell · 2013 · 10.1016/j.cell.2013.09.008

• Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

  Cell stem cell · 2013 · https://doi.org/10.1016/j.stem.2013.11.002

• ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

  Cell Reports · 2013 · 10.1016/j.celrep.2013.02.031

• The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

  The EMBO Journal · 2012 · https://doi.org/10.1038/emboj.2012.166

• Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

  Nature · 2012 · 10.1038/nature11308

• A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal

  Molecular and Cellular Biology · 2012 · 10.1128/mcb.06288-11

• Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

  Nature · 2011 · 10.1038/nature10337

• Controlled gene expression in primary Lgr5 organoid cultures

  Nature Methods · 2011 · 10.1038/nmeth.1802

• A crucial role of WW45 in developing epithelial tissues in the mouse

  The EMBO Journal · 2008 · https://doi.org/10.1038/emboj.2008.63

• Mind Bomb 1-Expressing Intermediate Progenitors Generate Notch Signaling to Maintain Radial Glial Cells

  Neuron · 2008 · 10.1016/j.neuron.2008.03.018

• Mind bomb 1 is essential for generating functional Notch ligands to activate Notch

  Development · 2005 · 10.1242/dev.01922

Current projects

No projects listed.