Vilhelm A. Bohr

Research interests

Publications

• NAD + supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

  Proceedings of the National Academy of Sciences · 2021 · https://doi.org/10.1073/pnas.2011226118

• Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

  Nature Neuroscience · 2019 · https://doi.org/10.1038/s41593-019-0372-9

• Ageing as a risk factor for neurodegenerative disease

  Nature Reviews Neurology · 2019 · https://doi.org/10.1038/s41582-019-0244-7

• Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

  Nature Neuroscience · 2019 · https://doi.org/10.1038/s41593-018-0332-9

• NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

  Proceedings of the National Academy of Sciences · 2018 · https://doi.org/10.1073/pnas.1718819115

• Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

  Cell Metabolism · 2018 · https://doi.org/10.1016/j.cmet.2018.02.001

• NAD + in Aging: Molecular Mechanisms and Translational Implications

  Trends in Molecular Medicine · 2017 · https://doi.org/10.1016/j.molmed.2017.08.001

• Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

  Trends in Neurosciences · 2017 · https://doi.org/10.1016/j.tins.2017.01.002

• Nuclear DNA damage signalling to mitochondria in ageing

  Nature Reviews Molecular Cell Biology · 2016 · https://doi.org/10.1038/nrm.2016.14

• Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

  Cell Metabolism · 2016 · https://doi.org/10.1016/j.cmet.2016.05.027

• NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

  Cell Metabolism · 2016 · https://doi.org/10.1016/j.cmet.2016.09.004

• A research agenda for aging in China in the 21st century

  Ageing Research Reviews · 2015 · https://doi.org/10.1016/j.arr.2015.08.003

• Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

  Cell Metabolism · 2015 · https://doi.org/10.1016/j.cmet.2015.10.013

• A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

  Cell Metabolism · 2014 · https://doi.org/10.1016/j.cmet.2014.10.005

• Metformin improves healthspan and lifespan in mice

  Nature Communications · 2013 · https://doi.org/10.1038/ncomms3192

• SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

  Nature · 2008 · https://doi.org/10.1038/nature06736

• Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

  Cell · 2007 · https://doi.org/10.1016/j.cell.2007.07.035

• Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

  Proceedings of the National Academy of Sciences · 2006 · https://doi.org/10.1073/pnas.0600645103

• p53 modulation of TFIIH–associated nucleotide excision repair activity

  Nature Genetics · 1995 · https://doi.org/10.1038/ng0695-188

• DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

  Cell · 1985 · https://doi.org/10.1016/0092-8674(85)90150-3

Current projects

No projects listed.