Paul D. Robbins

Research interests

Publications

• Guidelines for minimal information on cellular senescence experimentation in vivo

  Cell · 2024 · 10.1016/j.cell.2024.05.059

• A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

  Nature Communications · 2022 · 10.1038/s41467-022-32552-1

• Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

  FEBS Journal · 2022 · 10.1111/febs.16350

• Cellular senescence: a key therapeutic target in aging and diseases

  Journal of Clinical Investigation · 2022 · 10.1172/jci158450

• An aged immune system drives senescence and ageing of solid organs

  Nature · 2021 · 10.1038/s41586-021-03547-7

• Cellular Senescence: Defining a Path Forward

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.10.005

• Senolytics improve physical function and increase lifespan in old age

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0092-9

• Fisetin is a senotherapeutic that extends health and lifespan

  EBioMedicine · 2018 · 10.1016/j.ebiom.2018.09.015

• New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

  Aging · 2017 · 10.18632/aging.101202

• Cellular senescence mediates fibrotic pulmonary disease

  Nature Communications · 2017 · https://doi.org/10.1038/ncomms14532

• Identification of HSP90 inhibitors as a novel class of senolytics

  Nature Communications · 2017 · 10.1038/s41467-017-00314-z

• The Clinical Potential of Senolytic Drugs

  Journal of the American Geriatrics Society · 2017 · 10.1111/jgs.14969

• Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

  Aging Cell · 2015 · 10.1111/acel.12445

• The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

  Aging Cell · 2015 · https://doi.org/10.1111/acel.12344

• Regulation of immune responses by extracellular vesicles

  Nature reviews. Immunology · 2014 · https://doi.org/10.1038/nri3622

• NF-κB inhibition delays DNA damage–induced senescence and aging in mice

  Journal of Clinical Investigation · 2012 · 10.1172/jci45785

• SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

  PLoS ONE · 2010 · 10.1371/journal.pone.0009199

• Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

  Nature Medicine · 2009 · https://doi.org/10.1038/nm.2050

• Exosomes Derived from IL-10-Treated Dendritic Cells Can Suppress Inflammation and Collagen-Induced Arthritis

  The Journal of Immunology · 2005 · 10.4049/jimmunol.174.10.6440

• A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

  Nature · 2001 · 10.1038/35065125

• Negative regulation of the Apaf-1 apoptosome by Hsp70

  Nature Cell Biology · 2000 · 10.1038/35019510

• Clonal Isolation of Muscle-Derived Cells Capable of Enhancing Muscle Regeneration and Bone Healing

  The Journal of Cell Biology · 2000 · 10.1083/jcb.150.5.1085

• 1999 Volvo Award Winner in Basic Science Studies

  Spine · 1999 · 10.1097/00007632-199912010-00002

• Development of Approaches to Improve Cell Survival in Myoblast Transfer Therapy

  The Journal of Cell Biology · 1998 · 10.1083/jcb.142.5.1257

• In vivo suppression of early experimental osteoarthritis by interleukin‐1 receptor antagonist using gene therapy

  Arthritis & Rheumatism · 1997 · 10.1002/art.1780400604

Current projects

No projects listed.