Søren Brunak

Research interests

Publications

• The sequences of 150,119 genomes in the UK Biobank

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04965-x

• SignalP 6.0 predicts all five types of signal peptides using protein language models

  Repository for Publications and Research Data (ETH Zurich) · 2022 · 10.3929/ethz-b-000524414

• Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

  Nature · 2020 · https://doi.org/10.1038/s41586-020-1965-x

• SignalP 5.0 improves signal peptide predictions using deep neural networks

  Nature Biotechnology · 2019 · https://doi.org/10.1038/s41587-019-0036-z

• Human gut microbes impact host serum metabolome and insulin sensitivity

  Nature · 2016 · https://doi.org/10.1038/nature18646

• A genomic history of Aboriginal Australia

  Nature · 2016 · https://doi.org/10.1038/nature18299

• Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

  Nature Genetics · 2016 · 10.1038/ng.3528

• Population genomics of Bronze Age Eurasia

  Nature · 2015 · 10.1038/nature14507

• An integrated catalog of reference genes in the human gut microbiome

  Nature Biotechnology · 2014 · 10.1038/nbt.2942

• Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes

  Nature Biotechnology · 2014 · 10.1038/nbt.2939

• Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans

  Nature · 2013 · 10.1038/nature12736

• Richness of human gut microbiome correlates with metabolic markers

  Nature · 2013 · 10.1038/nature12506

• Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse

  Nature · 2013 · 10.1038/nature12323

• Precision mapping of the human O‐GalNAc glycoproteome through SimpleCell technology

  The EMBO Journal · 2013 · 10.1038/emboj.2013.79

• Mining electronic health records: towards better research applications and clinical care

  Nature Reviews Genetics · 2012 · 10.1038/nrg3208

• An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia

  Science · 2011 · 10.1126/science.1211177

• SignalP 4.0: discriminating signal peptides from transmembrane regions

  Nature Methods · 2011 · https://doi.org/10.1038/nmeth.1701

• Enterotypes of the human gut microbiome

  Nature · 2011 · https://doi.org/10.1038/nature09944

• Ancient human genome sequence of an extinct Palaeo-Eskimo

  Nature · 2010 · 10.1038/nature08835

• A human gut microbial gene catalogue established by metagenomic sequencing

  Nature · 2010 · https://doi.org/10.1038/nature08821

• Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

  Science Signaling · 2010 · 10.1126/scisignal.2000475

• Locating proteins in the cell using TargetP, SignalP and related tools

  Nature Protocols · 2007 · 10.1038/nprot.2007.131

• Improved Prediction of Signal Peptides: SignalP 3.0

  Journal of Molecular Biology · 2004 · https://doi.org/10.1016/j.jmb.2004.05.028

• Prediction of post‐translational glycosylation and phosphorylation of proteins from the amino acid sequence

  PROTEOMICS · 2004 · 10.1002/pmic.200300771

• Feature-based prediction of non-classical and leaderless protein secretion

  Protein Engineering Design and Selection · 2004 · 10.1093/protein/gzh037

• Prediction of lipoprotein signal peptides in Gram‐negative bacteria

  Protein Science · 2003 · 10.1110/ps.0303703

• Reliable prediction of T‐cell epitopes using neural networks with novel sequence representations

  Protein Science · 2003 · 10.1110/ps.0239403

• Prediction of glycosylation across the human proteome and the correlation to protein function

  Journal · 2001 · 10.1142/9789812799623_0029

• Assessing the accuracy of prediction algorithms for classification: an overview

  Bioinformatics · 2000 · 10.1093/bioinformatics/16.5.412

• Predicting Subcellular Localization of Proteins Based on their N-terminal Amino Acid Sequence

  Journal of Molecular Biology · 2000 · 10.1006/jmbi.2000.3903

• Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

  Journal of Molecular Biology · 1999 · 10.1006/jmbi.1999.3310

• Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

  Protein Engineering Design and Selection · 1997 · https://doi.org/10.1093/protein/10.1.1

Current projects

No projects listed.