Kasper Lage

Research interests

Publications

• The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits

  Cell Metabolism · 2023 · https://doi.org/10.1016/j.cmet.2023.03.001

• Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

  Nature Genetics · 2023 · https://doi.org/10.1038/s41588-023-01443-6

• Autism genes converge on asynchronous development of shared neuron classes

  Nature · 2022 · https://doi.org/10.1038/s41586-021-04358-6

• Assessment of network module identification across complex diseases

  Nature Methods · 2019 · https://doi.org/10.1038/s41592-019-0509-5

• A scored human protein–protein interaction network to catalyze genomic interpretation

  Nature Methods · 2016 · https://doi.org/10.1038/nmeth.4083

• Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles

  Cancer Discovery · 2016 · https://doi.org/10.1158/2159-8290.cd-16-0160

• Comprehensive assessment of cancer missense mutation clustering in protein structures

  Proceedings of the National Academy of Sciences · 2015 · https://doi.org/10.1073/pnas.1516373112

• An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge

  Genome biology · 2014 · https://doi.org/10.1186/gb-2014-15-3-r53

• Genome-wide meta-analysis identifies new susceptibility loci for migraine

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2676

• Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 Are Identified in Individuals with Congenital Hypogonadotropic Hypogonadism

  The American Journal of Human Genetics · 2013 · https://doi.org/10.1016/j.ajhg.2013.04.008

• Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics

  Science · 2013 · https://doi.org/10.1126/science.1235587

• Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination

  New England Journal of Medicine · 2013 · https://doi.org/10.1056/nejmoa1215993

• Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

  Cell Reports · 2012 · https://doi.org/10.1016/j.celrep.2012.07.006

• Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues

  Nature Communications · 2012 · https://doi.org/10.1038/ncomms1871

• Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries

  Cell · 2012 · https://doi.org/10.1016/j.cell.2012.03.028

• Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development

  Proceedings of the National Academy of Sciences · 2012 · https://doi.org/10.1073/pnas.1210730109

• Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

  PLoS Genetics · 2011 · https://doi.org/10.1371/journal.pgen.1001273

• Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

  The Journal of Cell Biology · 2010 · https://doi.org/10.1083/jcb.201005012

• A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0810772105

• A human phenome-interactome network of protein complexes implicated in genetic disorders

  Nature Biotechnology · 2007 · https://doi.org/10.1038/nbt1295

Current projects

No projects listed.