Mark A. Febbraio

Research interests

Publications

• Embracing cancer complexity: Hallmarks of systemic disease

  Cell · 2024 · https://doi.org/10.1016/j.cell.2024.02.009

• Exerkines in health, resilience and disease

  Nature Reviews Endocrinology · 2022 · https://doi.org/10.1038/s41574-022-00641-2

• Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

  Cell Metabolism · 2018 · https://doi.org/10.1016/j.cmet.2017.12.001

• Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

  Cell Metabolism · 2018 · 10.1016/j.cmet.2018.03.014

• Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

  Immunity · 2017 · 10.1016/j.immuni.2017.11.021

• Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

  Nature Immunology · 2014 · 10.1038/ni.2865

• Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

  Diabetologia · 2013 · 10.1007/s00125-013-2913-1

• The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

  Nature Immunology · 2013 · 10.1038/ni.2710

• Muscles, exercise and obesity: skeletal muscle as a secretory organ

  Nature Reviews Endocrinology · 2012 · https://doi.org/10.1038/nrendo.2012.49

• Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

  Diabetologia · 2009 · 10.1007/s00125-009-1364-1

• High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus

  Circulation · 2009 · 10.1161/circulationaha.108.843219

• Reactive Oxygen Species Enhance Insulin Sensitivity

  Cell Metabolism · 2009 · 10.1016/j.cmet.2009.08.009

• Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

  Physiological Reviews · 2008 · https://doi.org/10.1152/physrev.90100.2007

• HSP72 protects against obesity-induced insulin resistance

  Proceedings of the National Academy of Sciences · 2008 · 10.1073/pnas.0705799105

• Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

  Journal of Clinical Investigation · 2007 · 10.1172/jci31561

• Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

  Diabetes · 2006 · https://doi.org/10.2337/db05-1404

• Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

  Cell Metabolism · 2006 · 10.1016/j.cmet.2006.11.005

• Exosome-dependent Trafficking of HSP70

  Journal of Biological Chemistry · 2005 · 10.1074/jbc.m502017200

• Interleukin-6 Is a Novel Factor Mediating Glucose Homeostasis During Skeletal Muscle Contraction

  Diabetes · 2004 · 10.2337/diabetes.53.7.1643

• Searching for the exercise factor: is IL-6 a candidate?

  Journal of Muscle Research and Cell Motility · 2003 · 10.1023/a:1026070911202

• Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans

  The FASEB Journal · 2003 · 10.1096/fj.02-0670fje

• Interleukin-6 Stimulates Lipolysis and Fat Oxidation in Humans

  The Journal of Clinical Endocrinology & Metabolism · 2003 · 10.1210/jc.2002-021687

• Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles

  The FASEB Journal · 2002 · https://doi.org/10.1096/fj.01-0876rev

• IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle

  American Journal of Physiology-Endocrinology and Metabolism · 2002 · 10.1152/ajpendo.00255.2002

• Interleukin‐6 production in contracting human skeletal muscle is influenced by pre‐exercise muscle glycogen content

  The Journal of Physiology · 2001 · 10.1111/j.1469-7793.2001.00633.x

Current projects

No projects listed.