Niels Grarup

Research interests

Publications

• Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

  Nature · 2024 · https://doi.org/10.1038/s41586-024-07019-6

• Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-022-01058-3

• Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.06.045

• The Polygenic and Monogenic Basis of Blood Traits and Diseases

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.08.008

• Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0403-1

• Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0084-1

• A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

  Diabetes · 2018 · https://doi.org/10.2337/db17-0914

• Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0241-6

• Exome-wide association study of plasma lipids in >300,000 individuals

  Nature Genetics · 2017 · 10.1038/ng.3977

• An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

  Diabetes · 2017 · 10.2337/db16-1253

• PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

  The Lancet Diabetes & Endocrinology · 2016 · https://doi.org/10.1016/s2213-8587(16)30396-5

• Genome-wide associations for birth weight and correlations with adult disease

  Nature · 2016 · https://doi.org/10.1038/nature19806

• The genetic architecture of type 2 diabetes

  Nature · 2016 · 10.1038/nature18642

• Greenlandic Inuit show genetic signatures of diet and climate adaptation

  Science · 2015 · https://doi.org/10.1126/science.aab2319

• Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3405

• Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

  Human Molecular Genetics · 2015 · https://doi.org/10.1093/hmg/ddv472

• Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3437

• A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

  Nature · 2014 · https://doi.org/10.1038/nature13425

• Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.2915

• Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

  Diabetes · 2013 · https://doi.org/10.2337/db13-0949

• Richness of human gut microbiome correlates with metabolic markers

  Nature · 2013 · https://doi.org/10.1038/nature12506

• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.520

• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.609

• Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

  Nature Genetics · 2008 · https://doi.org/10.1038/ng.120

Current projects

No projects listed.