Karen Morrison

Research interests

Publications

• Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-26280-1

• Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00973-1

• Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

  Circulation · 2020 · https://doi.org/10.1161/circulationaha.120.045956

• Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease

  Brain · 2017 · https://doi.org/10.1093/brain/awx285

• Detection of long repeat expansions from PCR-free whole-genome sequence data

  Genome Research · 2017 · https://doi.org/10.1101/gr.225672.117

• Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis

  Science Translational Medicine · 2017 · https://doi.org/10.1126/scitranslmed.aad9157

• Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

  Nature Communications · 2017 · https://doi.org/10.1038/ncomms14774

• Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3622

• NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3626

• Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS

  Neuron · 2014 · https://doi.org/10.1016/j.neuron.2014.09.027

• Systematic Review and UK‐Based Study of PARK2 (parkin), PINK1, PARK7 (DJ‐1) and LRRK2 in early‐onset Parkinson's disease

  Movement Disorders · 2012 · https://doi.org/10.1002/mds.25132

• Large-scale replication and heterogeneity in Parkinson disease genetic loci

  Neurology · 2012 · https://doi.org/10.1212/wnl.0b013e318264e353

• Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

  The Lancet Neurology · 2012 · https://doi.org/10.1016/s1474-4422(12)70043-1

• EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force

  European Journal of Neurology · 2011 · https://doi.org/10.1111/j.1468-1331.2011.03501.x

• ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

  Nature Genetics · 2006 · https://doi.org/10.1038/ng1742

• ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

  Neurology · 2006 · https://doi.org/10.1212/01.wnl.0000231510.89311.8b

• VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

  Nature Genetics · 2003 · 10.1038/ng1211

Current projects

No projects listed.