Yifan Cheng

Research interests

Publications

• Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2668-z

• Single-particle cryo-EM—How did it get here and where will it go

  Science · 2018 · 10.1126/science.aat4346

• MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

  Nature Methods · 2017 · https://doi.org/10.1038/nmeth.4193

• Cryo-EM structures of the TMEM16A calcium-activated chloride channel

  Nature · 2017 · 10.1038/nature25024

• Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta

  eLife · 2016 · 10.7554/elife.17219

• TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

  Nature · 2016 · 10.1038/nature17964

• Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement

  Nature Methods · 2015 · https://doi.org/10.1038/nmeth.3286

• EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

  Nature Methods · 2015 · https://doi.org/10.1038/nmeth.3541

• Glycine receptor mechanism elucidated by electron cryo-microscopy

  Nature · 2015 · 10.1038/nature14853

• Structure of the TRPA1 ion channel suggests regulatory mechanisms

  Nature · 2015 · 10.1038/nature14367

• Single-Particle Cryo-EM at Crystallographic Resolution

  Cell · 2015 · 10.1016/j.cell.2015.03.049

• A Primer to Single-Particle Cryo-Electron Microscopy

  Cell · 2015 · 10.1016/j.cell.2015.03.050

• Structure of the TRPV1 ion channel determined by electron cryo-microscopy

  Nature · 2013 · https://doi.org/10.1038/nature12822

• TRPV1 structures in distinct conformations reveal activation mechanisms

  Nature · 2013 · https://doi.org/10.1038/nature12823

• Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

  Nature Methods · 2013 · https://doi.org/10.1038/nmeth.2472

• Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis

  Cell · 2013 · 10.1016/j.cell.2013.04.032

• Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

  Journal of Biological Chemistry · 2011 · 10.1074/jbc.m110.213538

• HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

  Traffic · 2009 · 10.1111/j.1600-0854.2009.01006.x

• Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases

  Molecular Cell · 2008 · 10.1016/j.molcel.2008.03.004

• Docking of the Proteasomal ATPases' Carboxyl Termini in the 20S Proteasome's α Ring Opens the Gate for Substrate Entry

  Molecular Cell · 2007 · 10.1016/j.molcel.2007.06.033

• Lipid–protein interactions in double-layered two-dimensional AQP0 crystals

  Nature · 2005 · 10.1038/nature04321

• Aquaporin-0 membrane junctions reveal the structure of a closed water pore

  Nature · 2004 · 10.1038/nature02503

• Structure of the Human Transferrin Receptor-Transferrin Complex

  Cell · 2004 · 10.1016/s0092-8674(04)00130-8

• Negative staining and image classification — powerful tools in modern electron microscopy

  Biological Procedures Online · 2004 · 10.1251/bpo70

• Molecular model for a complete clathrin lattice from electron cryomicroscopy

  Nature · 2004 · 10.1038/nature03079

Current projects

No projects listed.