Raphaël Gottardo

Research interests

Publications

• Multiple early factors anticipate post-acute COVID-19 sequelae

  Cell · 2022 · https://doi.org/10.1016/j.cell.2022.01.014

• Spatial transcriptomics at subspot resolution with BayesSpace

  Nature Biotechnology · 2021 · https://doi.org/10.1038/s41587-021-00935-2

• Integrated analysis of multimodal single-cell data

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.04.048

• Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.10.037

• Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

  Cancer Cell · 2020 · 10.1016/j.ccell.2020.11.005

• Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

  Nature Communications · 2020 · 10.1038/s41467-019-13880-1

• Orchestrating single-cell analysis with Bioconductor

  Nature Methods · 2019 · https://doi.org/10.1038/s41592-019-0654-x

• T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

  Nature Medicine · 2019 · 10.1038/s41591-019-0472-9

• Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA

  Nature Communications · 2018 · 10.1038/s41467-018-06300-3

• Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function

  Science Signaling · 2018 · 10.1126/scisignal.aat6753

• Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

  The Lancet · 2017 · 10.1016/s0140-6736(17)31665-3

• Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium

  Scientific Reports · 2016 · 10.1038/srep20686

• MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

  Genome biology · 2015 · 10.1186/s13059-015-0844-5

• Orchestrating high-throughput genomic analysis with Bioconductor

  Nature Methods · 2015 · 10.1038/nmeth.3252

• COMPASS identifies T-cell subsets correlated with clinical outcomes

  Nature Biotechnology · 2015 · 10.1038/nbt.3187

• Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

  Nucleic Acids Research · 2014 · 10.1093/nar/gku347

• OpenCyto: An Open Source Infrastructure for Scalable, Robust, Reproducible, and Automated, End-to-End Flow Cytometry Data Analysis

  PLoS Computational Biology · 2014 · 10.1371/journal.pcbi.1003806

• Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial

  PLoS ONE · 2013 · 10.1371/journal.pone.0075665

• Critical assessment of automated flow cytometry data analysis techniques

  Nature Methods · 2013 · 10.1038/nmeth.2365

• Global Panel of HIV-1 Env Reference Strains for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies

  Journal of Virology · 2013 · 10.1128/jvi.02853-13

• The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120

  AIDS Research and Human Retroviruses · 2012 · https://doi.org/10.1089/aid.2012.0103

• Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments

  Bioinformatics · 2012 · 10.1093/bioinformatics/bts714

• Combining Mixture Components for Clustering

  Journal of Computational and Graphical Statistics · 2010 · 10.1198/jcgs.2010.08111

• Automated gating of flow cytometry data via robust model‐based clustering

  Cytometry Part A · 2008 · 10.1002/cyto.a.20531

• Model-based analysis of tiling-arrays for ChIP-chip

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0601180103

Current projects

No projects listed.