Claudiu T. Supuran

Research interests

Publications

• Natural products in drug discovery: advances and opportunities

  Nature Reviews Drug Discovery · 2021 · https://doi.org/10.1038/s41573-020-00114-z

• The Warburg Effect and the Hallmarks of Cancer

  Anti-Cancer Agents in Medicinal Chemistry · 2017 · 10.2174/1871520616666161031143301

• Advances in structure-based drug discovery of carbonic anhydrase inhibitors

  Expert Opinion on Drug Discovery · 2016 · 10.1080/17460441.2017.1253677

• Structure and function of carbonic anhydrases

  Biochemical Journal · 2016 · 10.1042/bcj20160115

• Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX

  Journal of Medicinal Chemistry · 2015 · https://doi.org/10.1021/acs.jmedchem.5b01343

• How many carbonic anhydrase inhibition mechanisms exist?

  Journal of Enzyme Inhibition and Medicinal Chemistry · 2015 · 10.3109/14756366.2015.1122001

• An overview of the alpha-, beta- and gamma-carbonic anhydrases from Bacteria : can bacterial carbonic anhydrases shed new light on evolution of bacteria?

  Journal of Enzyme Inhibition and Medicinal Chemistry · 2014 · 10.3109/14756366.2014.910202

• A Small‐Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

  Angewandte Chemie International Edition · 2014 · https://doi.org/10.1002/anie.201310709

• Structure-based drug discovery of carbonic anhydrase inhibitors

  Journal of Enzyme Inhibition and Medicinal Chemistry · 2012 · 10.3109/14756366.2012.672983

• Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

  Oncotarget · 2012 · 10.18632/oncotarget.422

• Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

  Oncogene · 2012 · https://doi.org/10.1038/onc.2012.550

• Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

  Journal of Medicinal Chemistry · 2012 · https://doi.org/10.1021/jm301625s

• Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

  Chemical Reviews · 2012 · https://doi.org/10.1021/cr200176r

• Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

  Cancer Research · 2011 · 10.1158/0008-5472.can-10-4261

• Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

  Journal of Medicinal Chemistry · 2011 · 10.1021/jm101541x

• Interfering with pH regulation in tumours as a therapeutic strategy

  Nature Reviews Drug Discovery · 2011 · https://doi.org/10.1038/nrd3554

• Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors

  Journal of the American Chemical Society · 2009 · 10.1021/ja809683v

• Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

  Journal of Enzyme Inhibition and Medicinal Chemistry · 2009 · https://doi.org/10.1080/14756360902784425

• Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

  Proceedings of the National Academy of Sciences · 2009 · https://doi.org/10.1073/pnas.0908301106

• Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

  Nature Reviews Drug Discovery · 2008 · https://doi.org/10.1038/nrd2467

• Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes

  Journal of Biological Chemistry · 2008 · https://doi.org/10.1074/jbc.m800938200

• Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase Can2 from the Pathogenic Fungus Cryptococcus neoformans

  Journal of Molecular Biology · 2008 · https://doi.org/10.1016/j.jmb.2008.11.037

• Carbonic Anhydrases An Overview

  Current Pharmaceutical Design · 2008 · 10.2174/138161208783877884

• Carbonic anhydrases as targets for medicinal chemistry

  Bioorganic & Medicinal Chemistry · 2007 · 10.1016/j.bmc.2007.04.020

• Carbonic Anhydrase Inhibitors. Design of Fluorescent Sulfonamides as Probes of Tumor-Associated Carbonic Anhydrase IX That Inhibit Isozyme IX-Mediated Acidification of Hypoxic Tumors

  Journal of Medicinal Chemistry · 2005 · https://doi.org/10.1021/jm0501073

• Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides—a new target for the design of antitumor and antiglaucoma drugs?

  Bioorganic & Medicinal Chemistry Letters · 2005 · https://doi.org/10.1016/j.bmcl.2004.12.053

• Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH

  FEBS Letters · 2004 · https://doi.org/10.1016/j.febslet.2004.10.043

• Review Article

  Journal of Enzyme Inhibition and Medicinal Chemistry · 2004 · https://doi.org/10.1080/14756360410001689540

• Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib: New Pharmacological Opportunities Due to Related Binding Site Recognition

  Journal of Medicinal Chemistry · 2003 · 10.1021/jm030912m

• Protease inhibitors of the sulfonamide type: Anticancer, antiinflammatory, and antiviral agents

  Medicinal Research Reviews · 2003 · 10.1002/med.10047

• Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides

  Bioorganic & Medicinal Chemistry Letters · 2003 · https://doi.org/10.1016/s0960-894x(03)00091-x

• Anticancer and Antiviral Sulfonamides

  Current Medicinal Chemistry · 2003 · 10.2174/0929867033457647

• Carbonic anhydrase inhibitors

  Medicinal Research Reviews · 2002 · https://doi.org/10.1002/med.10025

• Carbonic anhydrase inhibitors and their therapeutic potential

  Expert Opinion on Therapeutic Patents · 2000 · 10.1517/13543776.10.5.575

Current projects

No projects listed.