Nicholas J. Ashton

Research interests

Publications

• Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology

  JAMA Neurology · 2024 · https://doi.org/10.1001/jamaneurol.2023.5319

• Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

  Nature Medicine · 2023 · 10.1038/s41591-023-02380-x

• A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases

  Nature Aging · 2023 · 10.1038/s43587-023-00471-5

• Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma Biomarkers

  JAMA Neurology · 2023 · 10.1001/jamaneurol.2022.5272

• Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

  Nature Reviews Neurology · 2022 · 10.1038/s41582-022-00665-2

• Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease

  Brain · 2022 · https://doi.org/10.1093/brain/awac333

• Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring

  Nature Medicine · 2022 · 10.1038/s41591-022-02074-w

• Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease

  Nature Medicine · 2022 · 10.1038/s41591-022-01925-w

• Biomarker modeling of Alzheimer’s disease using PET-based Braak staging

  Nature Aging · 2022 · 10.1038/s43587-022-00204-0

• Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography

  JAMA Neurology · 2022 · 10.1001/jamaneurol.2022.4485

• Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration

  Brain · 2022 · 10.1093/brain/awac407

• The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

  Alzheimer s & Dementia · 2021 · 10.1002/alz.12283

• Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease

  JAMA Neurology · 2021 · 10.1001/jamaneurol.2020.4986

• A multicentre validation study of the diagnostic value of plasma neurofilament light

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-23620-z

• Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum

  JAMA Neurology · 2021 · https://doi.org/10.1001/jamaneurol.2021.3671

• Microglial activation and tau propagate jointly across Braak stages

  Nature Medicine · 2021 · 10.1038/s41591-021-01456-w

• Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes

  JAMA Neurology · 2021 · 10.1001/jamaneurol.2021.2293

• Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease

  Alzheimer s & Dementia · 2021 · 10.1002/alz.12447

• Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer’s disease

  Brain · 2021 · https://doi.org/10.1093/brain/awab223

• Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

  The Lancet Neurology · 2020 · 10.1016/s1474-4422(20)30071-5

• Steroid‐Responsive Encephalitis in Coronavirus Disease 2019

  Annals of Neurology · 2020 · 10.1002/ana.25783

• Time course of phosphorylated-tau181 in blood across the Alzheimer’s disease spectrum

  Brain · 2020 · 10.1093/brain/awaa399

• Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19

  Neurology · 2020 · 10.1212/wnl.0000000000010111

• Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative

  Molecular Psychiatry · 2020 · 10.1038/s41380-020-00923-z

• Role of Oxygen in the Genesis of Retrolental Fibroplasia: A Preliminary Report

  British Journal of Ophthalmology · 1953 · 10.1136/bjo.37.9.513

Current projects

No projects listed.