Juan Carlos Izpisúa Belmonte

Research interests

Publications

• Universal DNA methylation age across mammalian tissues

  Nature Aging · 2023 · https://doi.org/10.1038/s43587-023-00462-6

• DNA methylation networks underlying mammalian traits

  Science · 2023 · https://doi.org/10.1126/science.abq5693

• Universal DNA methylation age across mammalian tissues

  bioRxiv (Cold Spring Harbor Laboratory) · 2021 · https://doi.org/10.1101/2021.01.18.426733

• Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.01.009

• Dissecting primate early post-implantation development using long-term in vitro embryo culture

  Science · 2019 · https://doi.org/10.1126/science.aaw5754

• Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network

  Cell stem cell · 2019 · https://doi.org/10.1016/j.stem.2019.06.009

• Forty years of IVF

  Fertility and Sterility · 2018 · https://doi.org/10.1016/j.fertnstert.2018.06.005

• Correction of a pathogenic gene mutation in human embryos

  Nature · 2017 · https://doi.org/10.1038/nature23305

• In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.11.052

• In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

  Nature · 2016 · https://doi.org/10.1038/nature20565

• A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

  Science · 2015 · https://doi.org/10.1126/science.aaa1356

• Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

  Nature Reviews Molecular Cell Biology · 2011 · https://doi.org/10.1038/nrm3043

• Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture

  Cell stem cell · 2011 · https://doi.org/10.1016/j.stem.2010.12.003

• Somatic coding mutations in human induced pluripotent stem cells

  Nature · 2011 · https://doi.org/10.1038/nature09805

• Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

  Nature · 2011 · https://doi.org/10.1038/nature09879

• Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

  Nature · 2010 · https://doi.org/10.1038/nature08899

• Linking the p53 tumour suppressor pathway to somatic cell reprogramming

  Nature · 2009 · https://doi.org/10.1038/nature08311

• Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

  Nature · 2009 · https://doi.org/10.1038/nature08129

• Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

  Nature Biotechnology · 2008 · https://doi.org/10.1038/nbt.1503

• Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

  Nature · 2002 · https://doi.org/10.1038/nature01245

• Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse

  Developmental Cell · 2001 · https://doi.org/10.1016/s1534-5807(01)00041-7

• Pitx2 determines left–right asymmetry of internal organs in vertebrates

  Nature · 1998 · https://doi.org/10.1038/29004

Current projects

No projects listed.