D. Gareth Evans

Research interests

Publications

• Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes

  JAMA Oncology · 2022 · https://doi.org/10.1001/jamaoncol.2021.6744

• Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation

  Genetics in Medicine · 2021 · https://doi.org/10.1038/s41436-021-01170-5

• Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0609-2

• Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0537-1

• Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

  Genetics in Medicine · 2019 · https://doi.org/10.1038/s41436-019-0596-9

• Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

  The American Journal of Human Genetics · 2018 · https://doi.org/10.1016/j.ajhg.2018.11.002

• Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

  Human Mutation · 2018 · https://doi.org/10.1002/humu.23406

• Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844–848

  The American Journal of Human Genetics · 2017 · https://doi.org/10.1016/j.ajhg.2017.12.001

• Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

  JAMA · 2017 · https://doi.org/10.1001/jama.2017.7112

• Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2016.69.4935

• Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk

  New England Journal of Medicine · 2015 · 10.1056/nejmsr1501341

• Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer

  JAMA · 2015 · https://doi.org/10.1001/jama.2014.5985

• DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

  PLoS Genetics · 2014 · https://doi.org/10.1371/journal.pgen.1004256

• Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE

  JNCI Journal of the National Cancer Institute · 2013 · 10.1093/jnci/djt095

• Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

  PLoS Genetics · 2013 · https://doi.org/10.1371/journal.pgen.1003212

• Cancer risk and genotype–phenotype correlations in PTEN hamartoma tumor syndrome

  Familial Cancer · 2013 · https://doi.org/10.1007/s10689-013-9674-3

• Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1 / 2 (CIMBA)

  Cancer Epidemiology Biomarkers & Prevention · 2012 · https://doi.org/10.1158/1055-9965.epi-11-0775

• Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

  Breast Cancer Research · 2011 · https://doi.org/10.1186/bcr3052

• Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer

  PLoS Biology · 2011 · https://doi.org/10.1371/journal.pbio.1001199

• Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

  The Lancet · 2011 · 10.1016/s0140-6736(11)61049-0

• Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)

  Gut · 2010 · 10.1136/gut.2009.179804

• Birth incidence and prevalence of tumor‐prone syndromes: Estimates from a UK family genetic register service

  American Journal of Medical Genetics Part A · 2010 · 10.1002/ajmg.a.33139

• Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

  Cancer Research · 2010 · https://doi.org/10.1158/0008-5472.can-10-1907

• A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.669

• Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.354

• A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

  Nature Genetics · 2008 · 10.1038/ng.111

• Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

  The American Journal of Human Genetics · 2008 · https://doi.org/10.1016/j.ajhg.2008.02.008

• Genome-wide association study identifies novel breast cancer susceptibility loci

  Nature · 2007 · 10.1038/nature05887

• PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

  Nature Genetics · 2006 · 10.1038/ng1959

• Guidelines for the diagnosis and management of individuals with neurofibromatosis 1

  Journal of Medical Genetics · 2006 · 10.1136/jmg.2006.045906

• Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS)

  The Lancet · 2005 · 10.1016/s0140-6736(05)66481-1

• Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

  Clinical Cancer Research · 2005 · 10.1158/1078-0432.ccr-04-2424

• Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group

  Journal of Clinical Oncology · 2004 · 10.1200/jco.2004.04.188

• Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies

  The American Journal of Human Genetics · 2003 · 10.1086/375033

• Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations

  New England Journal of Medicine · 2002 · 10.1056/nejmoa012158

• Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

  Nature Genetics · 2002 · 10.1038/ng879

• Malignant peripheral nerve sheath tumours in neurofibromatosis 1

  Journal of Medical Genetics · 2002 · 10.1136/jmg.39.5.311

• Epidemiology of Helicobacter pylori in an asymptomatic population in the United States

  Gastroenterology · 1991 · 10.1016/0016-5085(91)90644-z

Current projects

No projects listed.