David H. Rowitch

Research interests

Publications

• Reactive astrocyte nomenclature, definitions, and future directions

  Nature Neuroscience · 2021 · https://doi.org/10.1038/s41593-020-00783-4

• Neuronal vulnerability and multilineage diversity in multiple sclerosis

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1404-z

• Challenges to curing primary brain tumours

  Nature Reviews Clinical Oncology · 2019 · https://doi.org/10.1038/s41571-019-0177-5

• Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children

  Intensive Care Medicine · 2019 · https://doi.org/10.1007/s00134-019-05552-x

• Niche stiffness underlies the ageing of central nervous system progenitor cells

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1484-9

• Single-cell genomics identifies cell type–specific molecular changes in autism

  Science · 2019 · 10.1126/science.aav8130

• Single-cell reconstruction of the early maternal–fetal interface in humans

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0698-6

• Neurotoxic reactive astrocytes are induced by activated microglia

  Nature · 2017 · 10.1038/nature21029

• Functional diversity of astrocytes in neural circuit regulation

  Nature reviews. Neuroscience · 2016 · 10.1038/nrn.2016.159

• Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

  Science · 2012 · https://doi.org/10.1126/science.1222381

• Astrocytes and disease: a neurodevelopmental perspective

  Genes & Development · 2012 · https://doi.org/10.1101/gad.188326.112

• Corridors of migrating neurons in the human brain and their decline during infancy

  Nature · 2011 · 10.1038/nature10487

• The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma

  Cancer Cell · 2011 · https://doi.org/10.1016/j.ccr.2011.01.035

• Conserved role of intragenic DNA methylation in regulating alternative promoters

  Nature · 2010 · 10.1038/nature09165

• CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

  Cell stem cell · 2010 · https://doi.org/10.1016/j.stem.2010.04.002

• Developmental genetics of vertebrate glial–cell specification

  Nature · 2010 · 10.1038/nature09611

• Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

  Cell · 2009 · 10.1016/j.cell.2009.04.031

• Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

  Genes & Development · 2009 · 10.1101/gad.1806309

• Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

  Cancer Cell · 2008 · 10.1016/j.ccr.2008.07.005

• Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

  Cancer Cell · 2008 · 10.1016/j.ccr.2008.07.003

• Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma

  Neuron · 2007 · https://doi.org/10.1016/j.neuron.2007.01.009

• Development of NG2 neural progenitor cells requires Olig gene function

  Proceedings of the National Academy of Sciences · 2006 · https://doi.org/10.1073/pnas.0511001103

• Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain

  Journal of Neuroscience · 2006 · 10.1523/jneurosci.1299-06.2006

• Epidermal growth factor receptor and Ink4a/Arf

  Cancer Cell · 2002 · 10.1016/s1535-6108(02)00046-6

• Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection

  Cell · 2002 · https://doi.org/10.1016/s0092-8674(02)00678-5

• Malignant glioma: genetics and biology of a grave matter

  Genes & Development · 2001 · 10.1101/gad.891601

• Inactivation of the β-catenin gene by Wnt1-Cre -mediated deletion results in dramatic brain malformation and failure of craniofacial development

  Development · 2001 · 10.1242/dev.128.8.1253

• Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon

  Development · 2001 · https://doi.org/10.1242/dev.128.13.2545

• Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System

  Neuron · 2000 · 10.1016/s0896-6273(00)80897-1

• Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis

  Development · 2000 · 10.1242/dev.127.8.1671

• Fate of the mammalian cardiac neural crest

  Development · 2000 · 10.1242/dev.127.8.1607

• Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

  Current Biology · 1998 · 10.1016/s0960-9822(07)00562-3

Current projects

No projects listed.