Clive N. Svendsen

Research interests

Publications

• Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection

  Cell Reports Medicine · 2020 · https://doi.org/10.1016/j.xcrm.2020.100052

• Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery

  Cell stem cell · 2020 · https://doi.org/10.1016/j.stem.2020.02.011

• Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

  Cell stem cell · 2019 · https://doi.org/10.1016/j.stem.2019.05.011

• The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

  Cell Systems · 2017 · https://doi.org/10.1016/j.cels.2017.11.001

• Modeling ALS with motor neurons derived from human induced pluripotent stem cells

  Nature Neuroscience · 2016 · https://doi.org/10.1038/nn.4273

• In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa

  Molecular Therapy · 2015 · https://doi.org/10.1038/mt.2015.220

• Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

  Science Translational Medicine · 2013 · https://doi.org/10.1126/scitranslmed.3007529

• Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain

  Brain · 2011 · https://doi.org/10.1093/brain/awr094

• Induced pluripotent stem cells from a spinal muscular atrophy patient

  Nature · 2008 · https://doi.org/10.1038/nature07677

• GDNF Secreting Human Neural Progenitor Cells Protect Dying Motor Neurons, but Not Their Projection to Muscle, in a Rat Model of Familial ALS

  PLoS ONE · 2007 · https://doi.org/10.1371/journal.pone.0000689

• Intraputamenal infusion of glial cell line–derived neurotrophic factor in PD: A two‐year outcome study

  Annals of Neurology · 2005 · https://doi.org/10.1002/ana.20374

• Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

  Nature Medicine · 2003 · https://doi.org/10.1038/nm850

• Growth factors regulate the survival and fate of cells derived from human neurospheres

  Nature Biotechnology · 2001 · https://doi.org/10.1038/88158

• Human Neural Precursor Cells Express Low Levels of Telomerase in Vitro and Show Diminishing Cell Proliferation with Extensive Axonal Outgrowth following Transplantation

  Experimental Neurology · 2000 · https://doi.org/10.1006/exnr.2000.7427

• Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

  Neuron · 1999 · https://doi.org/10.1016/s0896-6273(00)80781-3

• Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity

  Proceedings of the National Academy of Sciences · 1998 · https://doi.org/10.1073/pnas.95.4.1852

• A new method for the rapid and long term growth of human neural precursor cells

  Journal of Neuroscience Methods · 1998 · https://doi.org/10.1016/s0165-0270(98)00126-5

• Fibroblast Growth Factor 2 (FGF-2) Promotes Acquisition of Epidermal Growth Factor (EGF) Responsiveness in Mouse Striatal Precursor Cells: Identification of Neural Precursors Responding to both EGF and FGF-2

  Journal of Neuroscience · 1998 · https://doi.org/10.1523/jneurosci.18-19-07869.1998

• Long-Term Survival of Human Central Nervous System Progenitor Cells Transplanted into a Rat Model of Parkinson's Disease

  Experimental Neurology · 1997 · https://doi.org/10.1006/exnr.1997.6634

• Survival and Differentiation of Rat and Human Epidermal Growth Factor-Responsive Precursor Cells Following Grafting into the Lesioned Adult Central Nervous System

  Experimental Neurology · 1996 · https://doi.org/10.1006/exnr.1996.0039

• Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons

  Science · 1990 · https://doi.org/10.1126/science.1688664

Current projects

No projects listed.