H. Phillip Koeffler

Research interests

Publications

• Maftools: efficient and comprehensive analysis of somatic variants in cancer

  Genome Research · 2018 · https://doi.org/10.1101/gr.239244.118

• Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

  Immunity · 2018 · https://doi.org/10.1016/j.immuni.2018.02.002

• Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms7042

• Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse

  Blood · 2015 · https://doi.org/10.1182/blood-2015-05-646240

• The genomic landscape of nasopharyngeal carcinoma

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.3006

• Landscape Of Genetic Lesions In 944 Patients With Myelodysplastic Syndromes

  Blood · 2013 · https://doi.org/10.1182/blood.v122.21.521.521

• Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

  Leukemia · 2013 · https://doi.org/10.1038/leu.2013.336

• Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2731

• Frequent pathway mutations of splicing machinery in myelodysplasia

  Nature · 2011 · https://doi.org/10.1038/nature10496

• Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.585

• Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

  Cancer Research · 2009 · https://doi.org/10.1158/0008-5472.can-09-0536

• Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

  Oncogene · 2008 · https://doi.org/10.1038/onc.2008.292

• 15-Hydroxyprostaglandin Dehydrogenase Is a Tumor Suppressor of Human Breast Cancer

  Cancer Research · 2006 · https://doi.org/10.1158/0008-5472.can-05-4368

• Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D 3

  The FASEB Journal · 2005 · https://doi.org/10.1096/fj.04-3284com

• Histone Deacetylase Inhibitors Have a Profound Antigrowth Activity in Endometrial Cancer Cells

  Clinical Cancer Research · 2004 · https://doi.org/10.1158/1078-0432.ccr-03-0100

• Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

  Blood · 2004 · https://doi.org/10.1182/blood-2004-04-1416

• Transferrin Receptor 2-α Supports Cell Growth Both in Iron-chelated Cultured Cells and in Vivo

  Journal of Biological Chemistry · 2000 · https://doi.org/10.1074/jbc.m908846199

• Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

  Proceedings of the National Academy of Sciences · 1998 · https://doi.org/10.1073/pnas.95.15.8806

• Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

  PubMed · 1998

• The Role of the Vitamin D Endocrine System in Health and Disease

  New England Journal of Medicine · 1989 · https://doi.org/10.1056/nejm198904133201506

Current projects

No projects listed.