K. Christopher García

Research interests

Publications

• Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04432-7

• Design of protein-binding proteins from the target structure alone

  Nature · 2022 · 10.1038/s41586-022-04654-9

• Accurate prediction of protein structures and interactions using a three-track neural network

  Science · 2021 · https://doi.org/10.1126/science.abj8754

• Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2080-8

• De novo design of potent and selective mimics of IL-2 and IL-15

  Nature · 2019 · 10.1038/s41586-018-0830-7

• In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles

  Nature Biotechnology · 2019 · 10.1038/s41587-019-0262-4

• Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

  Nature · 2018 · 10.1038/s41586-018-0178-z

• Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

  Nature · 2017 · 10.1038/nature22313

• Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

  Nature · 2017 · 10.1038/nature22323

• Deconstructing the Peptide-MHC Specificity of T Cell Recognition

  Cell · 2014 · 10.1016/j.cell.2014.03.047

• Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

  Nature Protocols · 2014 · 10.1038/nprot.2014.173

• Activation and allosteric modulation of a muscarinic acetylcholine receptor

  Nature · 2013 · https://doi.org/10.1038/nature12735

• Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

  Science · 2013 · 10.1126/science.1238856

• Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

  Nature · 2013 · 10.1038/nature12572

• Structural Basis of Wnt Recognition by Frizzled

  Science · 2012 · 10.1126/science.1222879

• The composition and signaling of the IL-35 receptor are unconventional

  Nature Immunology · 2012 · 10.1038/ni.2227

• Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

  Nature · 2012 · 10.1038/nature10975

• Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

  Cell · 2009 · 10.1016/j.cell.2009.09.025

• STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

  Cell · 2009 · https://doi.org/10.1016/j.cell.2009.02.014

• Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

  Cell · 2008 · 10.1016/j.cell.2007.12.030

• Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γ c Receptors

  Science · 2005 · 10.1126/science.1117893

• Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex

  Science · 2003 · 10.1126/science.1083901

• STRUCTURAL BASIS OF T CELL RECOGNITION

  Annual Review of Immunology · 1999 · 10.1146/annurev.immunol.17.1.369

• Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

  Science · 1998 · 10.1126/science.279.5354.1166

• An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

  Science · 1996 · 10.1126/science.274.5285.209

Current projects

No projects listed.