Stephen J. Elledge

Research interests

Publications

• Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

  Science · 2022 · 10.1126/science.abj8222

• Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

  Science · 2017 · 10.1126/science.aaf8399

• Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

  Nature · 2015 · https://doi.org/10.1038/nature14184

• Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

  Cell Host & Microbe · 2015 · https://doi.org/10.1016/j.chom.2015.11.002

• The DNA Damage Response: Making It Safe to Play with Knives

  Molecular Cell · 2010 · https://doi.org/10.1016/j.molcel.2010.09.019

• A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

  Cell · 2009 · 10.1016/j.cell.2009.05.006

• The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

  Cell · 2009 · https://doi.org/10.1016/j.cell.2009.12.017

• Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

  Cell · 2009 · 10.1016/j.cell.2009.02.024

• A quantitative atlas of mitotic phosphorylation

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0805139105

• Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

  Science · 2008 · 10.1126/science.1152725

• ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

  Science · 2007 · 10.1126/science.1140321

• The DNA Damage Response: Ten Years After

  Molecular Cell · 2007 · 10.1016/j.molcel.2007.11.015

• Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

  Science · 2003 · 10.1126/science.1083430

• Dicer is essential for mouse development

  Nature Genetics · 2003 · 10.1038/ng1253

• Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

  Nature · 2002 · 10.1038/416703a

• The DNA damage response: putting checkpoints in perspective

  Nature · 2000 · 10.1038/35044005

• Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

  Genes & Development · 2000 · 10.1101/gad.14.12.1448

• DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

  Science · 2000 · 10.1126/science.287.5459.1824

• BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

  Genes & Development · 2000 · 10.1101/gad.14.8.927

• Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

  Science · 1997 · 10.1126/science.277.5331.1497

• F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

  Cell · 1997 · 10.1016/s0092-8674(00)80403-1

• Cell Cycle Checkpoints: Preventing an Identity Crisis

  Science · 1996 · 10.1126/science.274.5293.1664

• SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

  Cell · 1996 · 10.1016/s0092-8674(00)80098-7

• Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

  Cell · 1995 · 10.1016/0092-8674(95)90039-x

• p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

  Cell · 1994 · 10.1016/0092-8674(94)90379-4

• The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

  Genes & Development · 1993 · 10.1101/gad.7.4.555

• Formation and Activation of a Cyclin E-cdk2 Complex During the G 1 Phase of the Human Cell Cycle

  Science · 1992 · 10.1126/science.1388288

Current projects

No projects listed.