Juan P. Casas

Research interests

Publications

• Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

  Science · 2024 · 10.1126/science.adj1182

• Preeclampsia and Cardiovascular Disease in a Large UK Pregnancy Cohort of Linked Electronic Health Records

  Circulation · 2019 · 10.1161/circulationaha.118.038080

• A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service

  The Lancet Digital Health · 2019 · 10.1016/s2589-7500(19)30012-3

• Plasma protein patterns as comprehensive indicators of health

  Nature Medicine · 2019 · 10.1038/s41591-019-0665-2

• Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.05.046

• The druggable genome and support for target identification and validation in drug development

  Science Translational Medicine · 2017 · https://doi.org/10.1126/scitranslmed.aag1166

• Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records

  BMJ · 2017 · 10.1136/bmj.j909

• Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus

  Circulation · 2017 · 10.1161/circulationaha.116.026560

• Selecting instruments for Mendelian randomization in the wake of genome-wide association studies

  International Journal of Epidemiology · 2016 · 10.1093/ije/dyw088

• Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

  Nature Communications · 2015 · 10.1038/ncomms9111

• Mendelian randomization of blood lipids for coronary heart disease

  European Heart Journal · 2014 · https://doi.org/10.1093/eurheartj/eht571

• Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

  Nature Genetics · 2012 · 10.1038/ng.1081

• Statins for the primary prevention of cardiovascular disease

  Cochrane Database of Systematic Reviews · 2011 · 10.1002/14651858.cd004816.pub4

• Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials

  The Lancet · 2011 · 10.1016/s0140-6736(11)60872-6

• CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events

  JAMA · 2011 · 10.1001/jama.2011.1880

• A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.694

• Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

  Nature Genetics · 2009 · 10.1038/ng.483

• C‐reactive protein and coronary heart disease: a critical review

  Journal of Internal Medicine · 2008 · 10.1111/j.1365-2796.2008.02015.x

• Non‐communicable diseases in low‐ and middle‐income countries: context, determinants and health policy

  Tropical Medicine & International Health · 2008 · 10.1111/j.1365-3156.2008.02116.x

• Homocysteine and stroke: evidence on a causal link from mendelian randomisation

  The Lancet · 2005 · 10.1016/s0140-6736(05)17742-3

• Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis

  The Lancet · 2005 · https://doi.org/10.1016/s0140-6736(05)67814-2

• Homocysteine and stroke: evidence on a causal link from mendelian randomisation

  The Lancet · 2005 · 10.1016/s0140-6736(05)70152-5

• Meta-analysis of Genetic Studies in Ischemic Stroke

  Archives of Neurology · 2004 · 10.1001/archneur.61.11.1652

• Endothelial Nitric Oxide Synthase Genotype and Ischemic Heart Disease

  Circulation · 2004 · 10.1161/01.cir.0000121357.76910.a3

• Is C-reactive protein an independent risk factor for essential hypertension?

  Journal of Hypertension · 2001 · 10.1097/00004872-200105000-00004

Current projects

No projects listed.