Daniel K. Nomura

Research interests

Publications

• Advances in covalent drug discovery

  Nature Reviews Drug Discovery · 2022 · https://doi.org/10.1038/s41573-022-00542-z

• Deubiquitinase-targeting chimeras for targeted protein stabilization

  Nature Chemical Biology · 2022 · 10.1038/s41589-022-00971-2

• The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1705-2

• Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

  Science Translational Medicine · 2019 · 10.1126/scitranslmed.aau5758

• ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

  Nature Cell Biology · 2019 · 10.1038/s41556-019-0391-5

• Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

  ACS Chemical Biology · 2019 · 10.1021/acschembio.8b01083

• Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

  Nature Chemical Biology · 2019 · 10.1038/s41589-019-0304-8

• Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism

  Nature · 2019 · 10.1038/s41586-019-1005-x

• Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

  Cell chemical biology · 2019 · https://doi.org/10.1016/j.chembiol.2018.11.016

• Cancer Metabolism: Current Understanding and Therapies

  Chemical Reviews · 2018 · 10.1021/acs.chemrev.7b00775

• A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

  Developmental Cell · 2017 · 10.1016/j.devcel.2017.11.020

• Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

  Science · 2017 · 10.1126/science.aag1417

• DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy

  Developmental Cell · 2017 · 10.1016/j.devcel.2017.06.003

• Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

  Nature Medicine · 2016 · https://doi.org/10.1038/nm.4055

• The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

  Cell · 2016 · 10.1016/j.cell.2016.05.071

• Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

  Cell Metabolism · 2016 · 10.1016/j.cmet.2016.01.019

• Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

  Cell Reports · 2014 · 10.1016/j.celrep.2014.11.018

• Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1310894110

• Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

  Science · 2011 · https://doi.org/10.1126/science.1209200

• Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

  Chemistry & Biology · 2011 · 10.1016/j.chembiol.2011.05.009

• Activity-based protein profiling for biochemical pathway discovery in cancer

  Nature reviews. Cancer · 2010 · 10.1038/nrc2901

• Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

  Nature Neuroscience · 2010 · 10.1038/nn.2616

• Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

  Cell · 2009 · 10.1016/j.cell.2009.11.027

• Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

  Proceedings of the National Academy of Sciences · 2009 · 10.1073/pnas.0909411106

• Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism

  Chemistry & Biology · 2009 · 10.1016/j.chembiol.2009.05.009

Current projects

No projects listed.