Hai Yan

Research interests

Publications

• Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

  Neuro-Oncology · 2022 · 10.1093/neuonc/noac207

• The implications of IDH mutations for cancer development and therapy

  Nature Reviews Clinical Oncology · 2021 · 10.1038/s41571-021-00521-0

• Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy

  Proceedings of the National Academy of Sciences · 2019 · 10.1073/pnas.1819799116

• Biological Role and Therapeutic Potential of IDH Mutations in Cancer

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.04.011

• Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA

  Acta Neuropathologica · 2018 · 10.1007/s00401-018-1936-6

• Identification of recurrent USP48 and BRAF mutations in Cushing’s disease

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-05275-5

• The genome-wide mutational landscape of pituitary adenomas

  Cell Research · 2016 · 10.1038/cr.2016.114

• Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

  European Journal of Cancer · 2015 · 10.1016/j.ejca.2015.03.010

• The H3.3 K27M mutation results in a poorer prognosis in brainstem gliomas than thalamic gliomas in adults

  Human Pathology · 2015 · https://doi.org/10.1016/j.humpath.2015.07.002

• Isocitrate dehydrogenase mutations in gliomas

  Neuro-Oncology · 2015 · 10.1093/neuonc/nov136

• Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.2995

• TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWAL

  Neuro-Oncology · 2014 · https://doi.org/10.1093/neuonc/nou206.18

• Mutations in IDH1 , IDH2 , and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

  Oncotarget · 2014 · https://doi.org/10.18632/oncotarget.1765

• The integrated landscape of driver genomic alterations in glioblastoma

  Nature Genetics · 2013 · 10.1038/ng.2734

• Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas

  Cancer Research · 2012 · https://doi.org/10.1158/0008-5472.can-12-2852

• Frequent ATRX , CIC , FUBP1 and IDH1 mutations refine the classification of malignant gliomas

  Oncotarget · 2012 · https://doi.org/10.18632/oncotarget.588

• A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation

  Genome Research · 2012 · 10.1101/gr.132738.111

• Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

  Nature · 2012 · https://doi.org/10.1038/nature10898

• Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

  Proceedings of the National Academy of Sciences · 2011 · 10.1073/pnas.1019393108

• Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types

  Human Mutation · 2011 · 10.1002/humu.21633

• Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma

  Science · 2011 · 10.1126/science.1210557

• Mutant Metabolic Enzymes Are at the Origin of Gliomas

  Cancer Research · 2009 · 10.1158/0008-5472.can-09-2650

• Glioblastoma multiforme: a review of therapeutic targets

  Expert Opinion on Therapeutic Targets · 2009 · 10.1517/14728220902942348

• IDH1 and IDH2 Mutations in Gliomas

  New England Journal of Medicine · 2009 · https://doi.org/10.1056/nejmoa0808710

• An Integrated Genomic Analysis of Human Glioblastoma Multiforme

  Science · 2008 · https://doi.org/10.1126/science.1164382

• High Frequency of Mutations of the PIK3CA Gene in Human Cancers

  Science · 2004 · https://doi.org/10.1126/science.1096502

• Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

  Cancer Research · 2004 · 10.1158/0008-5472.can-04-1170

• Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers

  Science · 2004 · 10.1126/science.1096096

Current projects

No projects listed.