David G. Huntsman

Research interests

Publications

• Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series

  Annals of Oncology · 2018 · 10.1093/annonc/mdy058

• Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline CDH1 sequence variants

  Human Mutation · 2018 · https://doi.org/10.1002/humu.23650

• Dose-Response Association of CD8 + Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

  JAMA Oncology · 2017 · https://doi.org/10.1001/jamaoncol.2017.3290

• Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3849

• Confirmation of ProMisE: A simple, genomics‐based clinical classifier for endometrial cancer

  Cancer · 2017 · 10.1002/cncr.30496

• Cancer-Associated Mutations in Endometriosis without Cancer

  New England Journal of Medicine · 2017 · 10.1056/nejmoa1614814

• Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3573

• Lapatinib or Trastuzumab Plus Taxane Therapy for Human Epidermal Growth Factor Receptor 2–Positive Advanced Breast Cancer: Final Results of NCIC CTG MA.31

  Journal of Clinical Oncology · 2015 · https://doi.org/10.1200/jco.2014.56.9590

• Hereditary Diffuse Gastric Cancer Syndrome

  JAMA Oncology · 2015 · 10.1001/jamaoncol.2014.168

• A clinically applicable molecular-based classification for endometrial cancers

  British Journal of Cancer · 2015 · 10.1038/bjc.2015.190

• Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

  Nature reviews. Cancer · 2015 · https://doi.org/10.1038/nrc4019

• Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

  Nature · 2014 · https://doi.org/10.1038/nature13952

• TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

  Genome Research · 2014 · https://doi.org/10.1101/gr.180281.114

• Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

  The Lancet Oncology · 2013 · https://doi.org/10.1016/s1470-2045(13)70253-5

• Distinct evolutionary trajectories of primary high‐grade serous ovarian cancers revealed through spatial mutational profiling

  The Journal of Pathology · 2013 · https://doi.org/10.1002/path.4230

• Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

  Journal of Clinical Investigation · 2012 · 10.1172/jci65833

• DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer

  Genome biology · 2012 · https://doi.org/10.1186/gb-2012-13-12-r124

• Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies

  The Lancet Oncology · 2012 · https://doi.org/10.1016/s1470-2045(11)70404-1

• The clonal and mutational evolution spectrum of primary triple-negative breast cancers

  Nature · 2012 · https://doi.org/10.1038/nature10933

• Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

  The Lancet Oncology · 2011 · 10.1016/s1470-2045(11)70214-5

• MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

  Nature · 2011 · 10.1038/nature09754

• deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data

  PLoS Computational Biology · 2011 · https://doi.org/10.1371/journal.pcbi.1001138

• Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers

  New England Journal of Medicine · 2011 · https://doi.org/10.1056/nejmoa1102903

• Integrated genomic analyses of ovarian carcinoma

  Nature · 2011 · https://doi.org/10.1038/nature10166

• Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies

  PLoS Medicine · 2010 · https://doi.org/10.1371/journal.pmed.1000279

• BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received

  British Journal of Cancer · 2010 · https://doi.org/10.1038/sj.bjc.6605736

• ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

  New England Journal of Medicine · 2010 · https://doi.org/10.1056/nejmoa1008433

• Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

  Nature · 2009 · 10.1038/nature08489

• Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary

  New England Journal of Medicine · 2009 · 10.1056/nejmoa0902542

• Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies

  PLoS Medicine · 2008 · 10.1371/journal.pmed.0050232

• Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma

  Cancer Cell · 2002 · 10.1016/s1535-6108(02)00180-0

Current projects

No projects listed.