A. Thomas Look

Research interests

Publications

• The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.03.008

• An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

  Science · 2014 · https://doi.org/10.1126/science.1259037

• A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

  Nature · 2009 · https://doi.org/10.1038/nature08119

• Acute lymphoblastic leukaemia

  The Lancet · 2008 · https://doi.org/10.1016/s0140-6736(08)60457-2

• Activating mutations in ALK provide a therapeutic target in neuroblastoma

  Nature · 2008 · https://doi.org/10.1038/nature07397

• FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

  The Journal of Experimental Medicine · 2007 · https://doi.org/10.1084/jem.20070876

• Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation

  Nature Medicine · 2006 · https://doi.org/10.1038/nm1512

• Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish

  Journal of Leukocyte Biology · 2006 · https://doi.org/10.1189/jlb.0506346

• NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

  Proceedings of the National Academy of Sciences · 2006 · https://doi.org/10.1073/pnas.0606108103

• Evidence for an Age Cutoff Greater Than 365 Days for Neuroblastoma Risk Group Stratification in the Children's Oncology Group

  Journal of Clinical Oncology · 2005 · https://doi.org/10.1200/jco.2005.05.571

• Chromosome 1p and 11q Deletions and Outcome in Neuroblastoma

  New England Journal of Medicine · 2005 · https://doi.org/10.1056/nejmoa052399

• tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

  Proceedings of the National Academy of Sciences · 2005 · https://doi.org/10.1073/pnas.0406252102

• BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma

  Current Biology · 2005 · https://doi.org/10.1016/j.cub.2005.01.031

• Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

  Science · 2004 · https://doi.org/10.1126/science.1102160

• The Use of Zebrafish to Understand Immunity

  Immunity · 2004 · https://doi.org/10.1016/s1074-7613(04)00084-6

• Myc-Induced T Cell Leukemia in Transgenic Zebrafish

  Science · 2003 · https://doi.org/10.1126/science.1080280

• Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

  Cancer Cell · 2002 · https://doi.org/10.1016/s1535-6108(02)00018-1

• Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

  Nature Medicine · 2000 · https://doi.org/10.1038/75007

• Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

  Proceedings of the National Academy of Sciences · 1998 · https://doi.org/10.1073/pnas.95.23.13765

• Oncogenic Transcription Factors in the Human Acute Leukemias

  Science · 1997 · https://doi.org/10.1126/science.278.5340.1059

• Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

  Science · 1994 · https://doi.org/10.1126/science.8122112

• Human aminopeptidase N is a receptor for human coronavirus 229E

  Nature · 1992 · https://doi.org/10.1038/357420a0

• Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy

  The Lancet · 1991 · https://doi.org/10.1016/0140-6736(91)90733-6

• Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study.

  Journal of Clinical Oncology · 1991 · https://doi.org/10.1200/jco.1991.9.4.581

• The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

  Cell · 1985 · https://doi.org/10.1016/s0092-8674(85)80047-7

Current projects

No projects listed.