Klaus Rajewsky

Research interests

Publications

• Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

  Nature Biotechnology · 2015 · 10.1038/nbt.3198

• MicroRNA Control in the Immune System: Basic Principles

  Cell · 2009 · 10.1016/j.cell.2008.12.027

• Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

  Nature Immunology · 2008 · 10.1038/ni1575

• MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb

  Cell · 2007 · 10.1016/j.cell.2007.07.021

• Regulation of the Germinal Center Response by MicroRNA-155

  Science · 2007 · https://doi.org/10.1126/science.1141229

• Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination

  Nature Immunology · 2006 · 10.1038/ni1357

• Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells

  Science · 2006 · 10.1126/science.1132742

• Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

  Genes & Development · 2005 · https://doi.org/10.1101/gad.1248505

• Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

  Nature Immunology · 2003 · 10.1038/ni907

• Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

  The Journal of Experimental Medicine · 2000 · https://doi.org/10.1084/jem.192.3.393

• Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

  The Journal of Experimental Medicine · 1998 · 10.1084/jem.188.9.1679

• In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

  Cell · 1997 · 10.1016/s0092-8674(00)80373-6

• Clonal selection and learning in the antibody system

  Nature · 1996 · https://doi.org/10.1038/381751a0

• Requirement of mammalian DNA polymerase-β in base-excision repair

  Nature · 1996 · 10.1038/379183a0

• Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

  Proceedings of the National Academy of Sciences · 1995 · 10.1073/pnas.92.2.377

• Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

  Nucleic Acids Research · 1995 · 10.1093/nar/23.24.5080

• Inducible Gene Targeting in Mice

  Science · 1995 · https://doi.org/10.1126/science.7660125

• Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning

  Nature · 1994 · 10.1038/367455a0

• Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

  Science · 1994 · 10.1126/science.8016642

• Interleukin-10-deficient mice develop chronic enterocolitis

  Cell · 1993 · 10.1016/0092-8674(93)80068-p

• Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

  Cell · 1993 · 10.1016/0092-8674(93)90644-6

• A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

  Nature · 1991 · 10.1038/350423a0

• Intraclonal generation of antibody mutants in germinal centres

  Nature · 1991 · 10.1038/354389a0

• Generation and Analysis of Interleukin-4 Deficient Mice

  Science · 1991 · 10.1126/science.1948049

• A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

  The Journal of Immunology · 1979 · 10.4049/jimmunol.123.4.1548

Current projects

No projects listed.