Donald E. Ingber

Research interests

Publications

• Human organs-on-chips for disease modelling, drug development and personalized medicine

  Nature Reviews Genetics · 2022 · 10.1038/s41576-022-00466-9

• COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03570-8

• Modelling cancer in microfluidic human organs-on-chips

  Nature reviews. Cancer · 2019 · 10.1038/s41568-018-0104-6

• Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

  Proceedings of the National Academy of Sciences · 2015 · 10.1073/pnas.1522193112

• Microfluidic organs-on-chips

  Nature Biotechnology · 2014 · https://doi.org/10.1038/nbt.2989

• Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

  Lab on a Chip · 2012 · 10.1039/c2lc40074j

• A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

  Science Translational Medicine · 2012 · 10.1126/scitranslmed.3004249

• From 3D cell culture to organs-on-chips

  Trends in Cell Biology · 2011 · 10.1016/j.tcb.2011.09.005

• Mechanical control of tissue and organ development

  Development · 2010 · 10.1242/dev.024166

• Reconstituting Organ-Level Lung Functions on a Chip

  Science · 2010 · https://doi.org/10.1126/science.1188302

• Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

  Nature Reviews Molecular Cell Biology · 2008 · 10.1038/nrm2594

• Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

  Nature · 2008 · https://doi.org/10.1038/nature06965

• Cellular mechanotransduction: putting all the pieces together again

  The FASEB Journal · 2006 · 10.1096/fj.05-5424rev

• Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement

  The Journal of Cell Biology · 2006 · 10.1083/jcb.200601060

• Cell Fates as High-Dimensional Attractor States of a Complex Gene Regulatory Network

  Physical Review Letters · 2005 · https://doi.org/10.1103/physrevlett.94.128701

• Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

  Nature Genetics · 2003 · 10.1038/ng1076

• Tensegrity I. Cell structure and hierarchical systems biology

  Journal of Cell Science · 2003 · 10.1242/jcs.00359

• Soft Lithography in Biology and Biochemistry

  Annual Review of Biomedical Engineering · 2001 · 10.1146/annurev.bioeng.3.1.335

• Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

  Proceedings of the National Academy of Sciences · 1997 · 10.1073/pnas.94.3.849

• TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION

  Annual Review of Physiology · 1997 · 10.1146/annurev.physiol.59.1.575

• Geometric Control of Cell Life and Death

  Science · 1997 · 10.1126/science.276.5317.1425

• Engineering Cell Shape and Function

  Science · 1994 · 10.1126/science.8171320

• Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

  Science · 1993 · 10.1126/science.7684161

• Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

  Journal of Cell Science · 1993 · 10.1242/jcs.104.3.613

• Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

  Nature · 1990 · 10.1038/348555a0

• Induction of angiogenesis during the transition from hyperplasia to neoplasia

  Nature · 1989 · 10.1038/339058a0

• A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

  PubMed · 1988

Current projects

No projects listed.