Samuel Aparício

Research interests

Publications

• The repertoire of mutational signatures in human cancer

  Nature · 2020 · https://doi.org/10.1038/s41586-020-1943-3

• Comprehensive molecular characterization of mitochondrial genomes in human cancers

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0557-x

• Pan-cancer analysis of whole genomes

  Nature · 2020 · https://doi.org/10.1038/s41586-020-1969-6

• Eleven grand challenges in single-cell data science

  Genome biology · 2020 · https://doi.org/10.1186/s13059-020-1926-6

• The landscape of viral associations in human cancers

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0558-9

• A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13825-8

• Divergent mutational processes distinguish hypoxic and normoxic tumours

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-14052-x

• CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

  Nature Communications · 2017 · 10.1038/ncomms14432

• The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.11.007

• The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

  Nature Communications · 2016 · 10.1038/ncomms11479

• Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

  Nature · 2014 · 10.1038/nature13952

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

  Nature · 2012 · https://doi.org/10.1038/nature10983

• The clonal and mutational evolution spectrum of primary triple-negative breast cancers

  Nature · 2012 · 10.1038/nature10933

• Mutational Processes Molding the Genomes of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.024

• The landscape of cancer genes and mutational processes in breast cancer

  Nature · 2012 · 10.1038/nature11017

• The Life History of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.023

• Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

  Nature Genetics · 2010 · 10.1038/ng.518

• ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

  New England Journal of Medicine · 2010 · 10.1056/nejmoa1008433

• Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

  Nature · 2009 · 10.1038/nature08489

• Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary

  New England Journal of Medicine · 2009 · 10.1056/nejmoa0902542

• The GPR54 Gene as a Regulator of Puberty

  New England Journal of Medicine · 2003 · https://doi.org/10.1056/nejmoa035322

Current projects

No projects listed.