Charles Swanton

Research interests

Publications

• Embracing cancer complexity: Hallmarks of systemic disease

  Cell · 2024 · https://doi.org/10.1016/j.cell.2024.02.009

• Cancer biomarkers: Emerging trends and clinical implications for personalized treatment

  Cell · 2024 · 10.1016/j.cell.2024.02.041

• Liquid Biopsy for Advanced NSCLC: A Consensus Statement From the International Association for the Study of Lung Cancer

  Journal of Thoracic Oncology · 2021 · https://doi.org/10.1016/j.jtho.2021.06.017

• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.03.009

• Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set

  Annals of Oncology · 2021 · 10.1016/j.annonc.2021.05.806

• Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.01.002

• Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

  Science · 2020 · 10.1126/science.abe1107

• Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

  Annals of Oncology · 2020 · https://doi.org/10.1016/j.annonc.2020.02.011

• Artificial intelligence in cancer imaging: Clinical challenges and applications

  CA A Cancer Journal for Clinicians · 2019 · 10.3322/caac.21552

• Neoantigen-directed immune escape in lung cancer evolution

  Nature · 2019 · 10.1038/s41586-019-1032-7

• Chromosomal instability drives metastasis through a cytosolic DNA response

  Nature · 2018 · 10.1038/nature25432

• Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic

  Annals of Oncology · 2018 · https://doi.org/10.1093/annonc/mdy495

• Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.018

• Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.01.018

• Renal cell carcinoma

  Nature Reviews Disease Primers · 2017 · https://doi.org/10.1038/nrdp.2017.9

• Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

  Cell · 2017 · 10.1016/j.cell.2017.10.001

• Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

  Cell · 2017 · 10.1016/j.cell.2017.10.001

• Tracking the Evolution of Non–Small-Cell Lung Cancer

  New England Journal of Medicine · 2017 · 10.1056/nejmoa1616288

• Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis

  The Lancet Oncology · 2017 · 10.1016/s1470-2045(17)30516-8

• deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

  Genome biology · 2016 · 10.1186/s13059-016-0893-4

• Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

  Science · 2016 · https://doi.org/10.1126/science.aaf1490

• Toward understanding and exploiting tumor heterogeneity

  Nature Medicine · 2015 · 10.1038/nm.3915

• Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

  Cancer Cell · 2015 · 10.1016/j.ccell.2014.12.001

• Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

  Science · 2014 · 10.1126/science.1253462

• Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

  Nature Genetics · 2014 · 10.1038/ng.2891

• The causes and consequences of genetic heterogeneity in cancer evolution

  Nature · 2013 · 10.1038/nature12625

• Replication stress links structural and numerical cancer chromosomal instability

  Nature · 2013 · 10.1038/nature11935

• Cancer heterogeneity: implications for targeted therapeutics

  British Journal of Cancer · 2013 · 10.1038/bjc.2012.581

• Intratumor Heterogeneity: Evolution through Space and Time

  Cancer Research · 2012 · 10.1158/0008-5472.can-12-2217

• Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1113205

Current projects

No projects listed.