Jonathan L. Tilly

Research interests

Publications

• Germline Energetics, Aging, and Female Infertility

  Cell Metabolism · 2013 · 10.1016/j.cmet.2013.05.007

• Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2669

• Bone Marrow Transplantation Generates Immature Oocytes and Rescues Long-Term Fertility in a Preclinical Mouse Model of Chemotherapy-Induced Premature Ovarian Failure

  Journal of Clinical Oncology · 2007 · 10.1200/jco.2006.10.3028

• Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood

  Cell · 2005 · https://doi.org/10.1016/j.cell.2005.06.031

• Germline stem cells and follicular renewal in the postnatal mammalian ovary

  Nature · 2004 · https://doi.org/10.1038/nature02316

• Ovarian follicle counts – not as simple as 1, 2, 3

  Reproductive Biology and Endocrinology · 2003 · 10.1186/1477-7827-1-11

• Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals

  Nature Genetics · 2001 · 10.1038/ng575

• Commuting the death sentence: how oocytes strive to survive

  Nature Reviews Molecular Cell Biology · 2001 · 10.1038/35099086

• A sperm ion channel required for sperm motility and male fertility

  Nature · 2001 · https://doi.org/10.1038/35098027

• Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

  Nature Medicine · 2000 · 10.1038/80442

• Oocyte Apoptosis: Like Sand through an Hourglass

  Developmental Biology · 1999 · 10.1006/dbio.1999.9344

• Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency

  Nature Genetics · 1999 · 10.1038/5985

• Defects in regulation of apoptosis in caspase-2-deficient mice

  Genes & Development · 1998 · https://doi.org/10.1101/gad.12.9.1304

• Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction

  Nature Medicine · 1997 · 10.1038/nm1197-1228

• Apoptosis and ovarian function

  Reviews of Reproduction · 1996 · 10.1530/ror.0.0010162

• Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium

  Journal of Cell Science · 1996 · 10.1242/jcs.109.3.631

• Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad.

  Endocrinology · 1995 · 10.1210/endo.136.8.7628407

• Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles.

  Endocrinology · 1995 · 10.1210/endo.136.1.7828537

• Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels.

  Endocrinology · 1995 · 10.1210/endo.136.1.7828536

• Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I.

  Endocrinology · 1994 · 10.1210/endo.135.5.7525255

• Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation

  Journal of Cellular Physiology · 1993 · 10.1002/jcp.1041540310

• Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors.

  Molecular Endocrinology · 1993 · 10.1210/mend.7.5.8316250

• Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism.

  Molecular Endocrinology · 1992 · 10.1210/mend.6.11.1480180

• INVOLVEMENT OF APOPTOSIS IN OVARIAN FOLLICULAR ATRESIA AND POSTOVULATORY REGRESSION

  Endocrinology · 1991 · 10.1210/endo-129-5-2799

Current projects

No projects listed.