Juan Iovanna

Research interests

Publications

• Activation of lysosomal iron triggers ferroptosis in cancer

  Nature · 2025 · https://doi.org/10.1038/s41586-025-08974-4

• A guideline on the molecular ecosystem regulating ferroptosis

  Nature Cell Biology · 2024 · https://doi.org/10.1038/s41556-024-01360-8

• Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features

  Gastroenterology · 2018 · https://doi.org/10.1053/j.gastro.2018.08.033

• Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

  Cellular Immunology · 2018 · https://doi.org/10.1016/j.cellimm.2018.01.013

• Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04383-6

• Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

  Nature Communications · 2017 · https://doi.org/10.1038/ncomms16031

• Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness

  Journal of Clinical Investigation · 2016 · https://doi.org/10.1172/jci87734

• GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

  Gut · 2016 · https://doi.org/10.1136/gutjnl-2015-311256

• Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

  Proceedings of the National Academy of Sciences · 2015 · https://doi.org/10.1073/pnas.1421601112

• Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

  Proceedings of the National Academy of Sciences · 2013 · https://doi.org/10.1073/pnas.1219555110

• Zymophagy, a Novel Selective Autophagy Pathway Mediated by VMP1-USP9x-p62, Prevents Pancreatic Cell Death*

  Journal of Biological Chemistry · 2010 · https://doi.org/10.1074/jbc.m110.197301

• DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

  Proceedings of the National Academy of Sciences · 2009 · https://doi.org/10.1073/pnas.0812745106

• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

  Journal of Clinical Investigation · 2009 · https://doi.org/10.1172/jci37948

• TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

  Genes & Development · 2008 · https://doi.org/10.1101/gad.1695308

• The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells

  Journal of Biological Chemistry · 2007 · https://doi.org/10.1074/jbc.m706956200

• Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

  Proceedings of the National Academy of Sciences · 2007 · https://doi.org/10.1073/pnas.0703942104

• The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells

  Cancer Cell · 2006 · https://doi.org/10.1016/j.ccr.2006.03.005

• Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes

  Cancer Research · 2006 · https://doi.org/10.1158/0008-5472.can-06-0169

• Cloning and Expression of the Rat p8 cDNA, a New Gene Activated in Pancreas during the Acute Phase of Pancreatitis, Pancreatic Development, and Regeneration, and Which Promotes Cellular Growth

  Journal of Biological Chemistry · 1997 · https://doi.org/10.1074/jbc.272.51.32360

Current projects

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