Wesley C. Van Voorhis

Research interests

Publications

• Accurate de novo design of membrane-traversing macrocycles

  Cell · 2022 · 10.1016/j.cell.2022.07.019

• SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape

  Cell Host & Microbe · 2022 · 10.1016/j.chom.2022.01.005

• Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

  Cell · 2021 · 10.1016/j.cell.2021.09.015

• SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern

  Science · 2021 · 10.1126/science.abi7994

• Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants

  Science · 2021 · 10.1126/science.abl8506

• Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

  Proceedings of the National Academy of Sciences · 2019 · 10.1073/pnas.1814685116

• Malaria

  Nature Reviews Disease Primers · 2017 · https://doi.org/10.1038/nrdp.2017.50

• Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

  PLoS Pathogens · 2016 · 10.1371/journal.ppat.1005763

• Malaria medicines: a glass half full?

  Nature Reviews Drug Discovery · 2015 · 10.1038/nrd4573

• Chemical genetics of Plasmodium falciparum

  Nature · 2010 · https://doi.org/10.1038/nature09099

• Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

  Nature Structural & Molecular Biology · 2010 · 10.1038/nsmb.1818

• Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

  PLoS neglected tropical diseases · 2010 · 10.1371/journal.pntd.0000804

• Genomic-scale prioritization of drug targets: the TDR Targets database

  Nature Reviews Drug Discovery · 2008 · 10.1038/nrd2684

• Therapeutic intervention based on protein prenylation and associated modifications

  Nature Chemical Biology · 2006 · 10.1038/nchembio818

• Heterologous expression of proteins from Plasmodium falciparum: Results from 1000 genes

  Molecular and Biochemical Parasitology · 2006 · https://doi.org/10.1016/j.molbiopara.2006.03.011

• Protein Farnesyltransferase Inhibitors Exhibit Potent Antimalarial Activity

  Journal of Medicinal Chemistry · 2005 · 10.1021/jm0491039

• Treponema pallidum Major Sheath Protein Homologue Tpr K Is a Target of Opsonic Antibody and the Protective Immune Response

  The Journal of Experimental Medicine · 1999 · 10.1084/jem.189.4.647

• Hepatic Mucormycosis in a Bone Marrow Transplant Recipient Who Ingested Naturopathic Medicine

  Clinical Infectious Diseases · 1996 · 10.1093/clinids/22.3.521

• Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase

  Antimicrobial Agents and Chemotherapy · 1996 · 10.1128/aac.40.11.2592

• Review: Nomenclature and Biologic Significance of Cytokines Involved in Inflammation and the Host Immune Response

  The Journal of Infectious Diseases · 1995 · 10.1093/infdis/172.6.1573

• Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man.

  Proceedings of the National Academy of Sciences · 1983 · 10.1073/pnas.80.19.6041

• Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages.

  The Journal of Experimental Medicine · 1983 · 10.1084/jem.158.1.126

• Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies.

  Proceedings of the National Academy of Sciences · 1983 · https://doi.org/10.1073/pnas.80.18.5699

• Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication.

  The Journal of Experimental Medicine · 1983 · 10.1084/jem.158.1.174

• The Cutaneous Infiltrates of Leprosy

  New England Journal of Medicine · 1982 · 10.1056/nejm198212233072601

Current projects

No projects listed.