Frederik Barkhof

Research interests

Publications

• Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation

  JAMA Neurology · 2024 · https://doi.org/10.1001/jamaneurol.2024.3770

• Dementia prevention in memory clinics: recommendations from the European task force for brain health services

  The Lancet Regional Health - Europe · 2023 · https://doi.org/10.1016/j.lanepe.2022.100576

• Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease

  The Journal of Prevention of Alzheimer s Disease · 2022 · https://doi.org/10.14283/jpad.2022.30

• Multiple sclerosis progression: time for a new mechanism-driven framework

  The Lancet Neurology · 2022 · https://doi.org/10.1016/s1474-4422(22)00289-7

• 2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis

  The Lancet Neurology · 2021 · 10.1016/s1474-4422(21)00095-8

• 2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis

  The Lancet Neurology · 2021 · 10.1016/s1474-4422(21)00095-8

• Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

  The Lancet Neurology · 2019 · https://doi.org/10.1016/s1474-4422(19)30283-2

• Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

  The Lancet Neurology · 2017 · https://doi.org/10.1016/s1474-4422(17)30159-x

• Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

  The Lancet Neurology · 2017 · https://doi.org/10.1016/s1474-4422(17)30470-2

• MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines

  The Lancet Neurology · 2016 · https://doi.org/10.1016/s1474-4422(15)00393-2

• Prevalence of Amyloid PET Positivity in Dementia Syndromes

  JAMA · 2015 · https://doi.org/10.1001/jama.2015.4669

• Atrophy patterns in early clinical stages across distinct phenotypes of A lzheimer's disease

  Human Brain Mapping · 2015 · https://doi.org/10.1002/hbm.22927

• The EADC‐ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

  Alzheimer s & Dementia · 2014 · https://doi.org/10.1016/j.jalz.2014.05.1756

• Resting-State Functional MR Imaging: A New Window to the Brain

  Radiology · 2014 · https://doi.org/10.1148/radiol.14132388

• Defining the clinical course of multiple sclerosis

  Neurology · 2014 · https://doi.org/10.1212/wnl.0000000000000560

• Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

  The Lancet Neurology · 2013 · https://doi.org/10.1016/s1474-4422(13)70124-8

• Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity

  PLoS ONE · 2010 · https://doi.org/10.1371/journal.pone.0013788

• Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

  Journal of Neurology Neurosurgery & Psychiatry · 2010 · 10.1136/jnnp.2009.204685

• Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

  New England Journal of Medicine · 2010 · https://doi.org/10.1056/nejmoa0907839

• Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

  BMJ · 2009 · https://doi.org/10.1136/bmj.b2477

• Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease

  NeuroImage · 2009 · https://doi.org/10.1016/j.neuroimage.2009.09.001

• White matter tract integrity in aging and Alzheimer's disease

  Human Brain Mapping · 2008 · https://doi.org/10.1002/hbm.20563

• Precuneus atrophy in early-onset Alzheimer’s disease: a morphometric structural MRI study

  Neuroradiology · 2007 · https://doi.org/10.1007/s00234-007-0269-2

• Reduced resting-state brain activity in the “default network” in normal aging

  Cerebral Cortex · 2007 · 10.1093/cercor/bhm207

• Consistent resting-state networks across healthy subjects

  Proceedings of the National Academy of Sciences · 2006 · https://doi.org/10.1073/pnas.0601417103

• Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study

  Human Brain Mapping · 2005 · 10.1002/hbm.20160

• Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease

  NeuroImage · 2004 · https://doi.org/10.1016/j.neuroimage.2004.07.006

• Noradrenaline mediates amygdala activation in men and women during encoding of emotional material

  NeuroImage · 2004 · https://doi.org/10.1016/j.neuroimage.2004.09.011

• A comprehensive study of gray matter loss in patients with Alzheimer’s disease using optimized voxel-based morphometry

  NeuroImage · 2003 · https://doi.org/10.1016/s1053-8119(03)00041-7

• Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study

  The Lancet · 2001 · 10.1016/s0140-6736(00)04725-5

• A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT

  Stroke · 2001 · 10.1161/01.str.32.6.1318

• Functional MR imaging in Alzheimer's disease during memory encoding.

  PubMed · 2001

• fMRI of visual encoding: Reproducibility of activation

  Human Brain Mapping · 2000 · https://doi.org/10.1002/(sici)1097-0193(200003)9:3<156::aid-hbm4>3.0.co;2-q

• Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways

  Hippocampus · 2000 · https://doi.org/10.1002/1098-1063(2000)10:4<398::aid-hipo6>3.0.co;2-k

• Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis

  Brain · 1997 · 10.1093/brain/120.11.2059

• A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging

  Journal of the Neurological Sciences · 1993 · 10.1016/0022-510x(93)90041-v

• Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates.

  Journal of Neurology Neurosurgery & Psychiatry · 1992 · 10.1136/jnnp.55.10.967

Current projects

No projects listed.