Michael T. Heneka

Research interests

Publications

• Microglia states and nomenclature: A field at its crossroads

  Neuron · 2022 · https://doi.org/10.1016/j.neuron.2022.10.020

• Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

  JAMA Neurology · 2022 · https://doi.org/10.1001/jamaneurol.2021.5216

• Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

  Acta Neuropathologica · 2022 · https://doi.org/10.1007/s00401-022-02454-z

• NLRP3 inflammasome activation drives tau pathology

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1769-z

• Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

  Nature · 2017 · https://doi.org/10.1038/nature25158

• A guiding map for inflammation

  Nature Immunology · 2017 · https://doi.org/10.1038/ni.3790

• Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

  Science Translational Medicine · 2016 · https://doi.org/10.1126/scitranslmed.aad6100

• sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

  EMBO Molecular Medicine · 2016 · https://doi.org/10.15252/emmm.201506123

• EFNS ‐ ENS / EAN Guideline on concomitant use of cholinesterase inhibitors and memantine in moderate to severe Alzheimer's disease

  European Journal of Neurology · 2015 · https://doi.org/10.1111/ene.12707

• Neuroinflammation in Alzheimer's disease

  The Lancet Neurology · 2015 · https://doi.org/10.1016/s1474-4422(15)70016-5

• Innate immunity in Alzheimer's disease

  Nature Immunology · 2015 · 10.1038/ni.3102

• Innate immune activation in neurodegenerative disease

  Nature reviews. Immunology · 2014 · https://doi.org/10.1038/nri3705

• Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration

  Acta Neuropathologica · 2014 · https://doi.org/10.1007/s00401-014-1298-7

• TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

  Science Translational Medicine · 2014 · https://doi.org/10.1126/scitranslmed.3009093

• CSF biomarker variability in the Alzheimer's Association quality control program

  Alzheimer s & Dementia · 2013 · https://doi.org/10.1016/j.jalz.2013.01.010

• NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

  Nature · 2012 · https://doi.org/10.1038/nature11729

• A Pan‐ E uropean Study of the C9orf72 Repeat Associated with FTLD : Geographic Prevalence, Genomic Instability, and Intermediate Repeats

  Human Mutation · 2012 · https://doi.org/10.1002/humu.22244

• The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

  Alzheimer s & Dementia · 2011 · https://doi.org/10.1016/j.jalz.2011.05.2243

• TLR2 Is a Primary Receptor for Alzheimer’s Amyloid β Peptide To Trigger Neuroinflammatory Activation

  The Journal of Immunology · 2011 · https://doi.org/10.4049/jimmunol.1101121

Current projects

No projects listed.