Chia‐Yen Chen

Research interests

Publications

• Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

  Nature Genetics · 2024 · https://doi.org/10.1038/s41588-024-01707-9

• Plasma proteomic associations with genetics and health in the UK Biobank

  Nature · 2023 · https://doi.org/10.1038/s41586-023-06592-6

• Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases

  Nature Genetics · 2023 · 10.1038/s41588-023-01300-6

• FinnGen provides genetic insights from a well-phenotyped isolated population

  Nature · 2023 · https://doi.org/10.1038/s41586-022-05473-8

• Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia

  Nature Genetics · 2022 · 10.1038/s41588-022-01034-x

• Mapping genomic loci implicates genes and synaptic biology in schizophrenia

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04434-5

• Improving polygenic prediction in ancestrally diverse populations

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-022-01054-7

• FinnGen: Unique genetic insights from combining isolated population and national health register data

  medRxiv · 2022 · https://doi.org/10.1101/2022.03.03.22271360

• Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

  Cell Genomics · 2022 · https://doi.org/10.1016/j.xgen.2022.100192

• Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01371-0

• Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00885-0

• The role of polygenic risk and susceptibility genes in breast cancer over the course of life

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-19966-5

• An Exposure-Wide and Mendelian Randomization Approach to Identifying Modifiable Factors for the Prevention of Depression

  American Journal of Psychiatry · 2020 · 10.1176/appi.ajp.2020.19111158

• Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults

  JAMA Psychiatry · 2019 · https://doi.org/10.1001/jamapsychiatry.2018.4175

• Comparative genetic architectures of schizophrenia in East Asian and European populations

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0512-x

• Genetic architecture of human plasma lipidome and its link to cardiovascular disease

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-11954-8

• Polygenic prediction via Bayesian regression and continuous shrinkage priors

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-09718-5

• International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-12576-w

• Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.08.051

• Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

  Nature Genetics · 2019 · 10.1038/s41588-018-0309-3

• Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems

  American Journal of Psychiatry · 2019 · 10.1176/appi.ajp.2019.18091085

• Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0099-7

• Publisher Correction: Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

  Nature Genetics · 2018 · 10.1038/s41588-018-0164-2

• Phenome-wide heritability analysis of the UK Biobank

  PLoS Genetics · 2017 · 10.1371/journal.pgen.1006711

• Being overweight or obese and risk of developing rheumatoid arthritis among women: a prospective cohort study

  Annals of the Rheumatic Diseases · 2014 · 10.1136/annrheumdis-2014-205459

• Improved ancestry inference using weights from external reference panels

  Bioinformatics · 2013 · 10.1093/bioinformatics/btt144

• NEAT1 Long Noncoding RNA and Paraspeckle Bodies Modulate HIV-1 Posttranscriptional Expression

  mBio · 2013 · 10.1128/mbio.00596-12

• Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies

  Cell · 2012 · 10.1016/j.cell.2012.01.059

Current projects

No projects listed.