Bernhard K. Keppler

Research interests

Publications

• Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development

  Antioxidants and Redox Signaling · 2018 · 10.1089/ars.2017.7487

• Metal Drugs and the Anticancer Immune Response

  Chemical Reviews · 2018 · 10.1021/acs.chemrev.8b00396

• Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development

  Chemical Society Reviews · 2017 · https://doi.org/10.1039/c7cs00332c

• NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

  Chemical Science · 2014 · 10.1039/c3sc53243g

• Anticancer Activity of Metal Complexes: Involvement of Redox Processes

  Antioxidants and Redox Signaling · 2011 · https://doi.org/10.1089/ars.2010.3663

• Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

  Anti-Cancer Drugs · 2009 · https://doi.org/10.1097/cad.0b013e328322fbc5

• Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity

  Journal of Medicinal Chemistry · 2009 · https://doi.org/10.1021/jm8013234

• Resistance against novel anticancer metal compounds: Differences and similarities

  Drug Resistance Updates · 2008 · https://doi.org/10.1016/j.drup.2008.02.002

• KP1019, A New Redox‐Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

  Chemistry & Biodiversity · 2008 · https://doi.org/10.1002/cbdv.200890195

• Influence of the Spacer Length on the in Vitro Anticancer Activity of Dinuclear Ruthenium−Arene Compounds

  Organometallics · 2008 · https://doi.org/10.1021/om800207t

• Structure−Activity Relationships for NAMI-A-type Complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = Imidazole, Indazole, 1,2,4-Triazole, 4-Amino-1,2,4-triazole, and 1-Methyl-1,2,4-triazole): Aquation, Redox Properties, Protein Binding, and Antiproliferative Activity

  Journal of Medicinal Chemistry · 2007 · https://doi.org/10.1021/jm061081y

• Antitumour metal compounds: more than theme and variations

  Dalton Transactions · 2007 · https://doi.org/10.1039/b712656p

• Gold(III) compounds as anticancer agents: Relevance of gold–protein interactions for their mechanism of action

  Journal of Inorganic Biochemistry · 2007 · https://doi.org/10.1016/j.jinorgbio.2007.11.003

• Redox behavior of tumor-inhibiting ruthenium( iii ) complexes and effects of physiological reductants on their binding to GMP

  Dalton Transactions · 2006 · https://doi.org/10.1039/b511792e

• Interactions of Antitumor Metallodrugs with Serum Proteins: Advances in Characterization Using Modern Analytical Methodology

  Chemical Reviews · 2006 · https://doi.org/10.1021/cr040704h

• From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)

  Journal of Inorganic Biochemistry · 2006 · https://doi.org/10.1016/j.jinorgbio.2006.02.013

• Update of the Preclinical Situation of Anticancer Platinum Complexes: Novel Design Strategies and Innovative Analytical Approaches

  Current Medicinal Chemistry · 2005 · https://doi.org/10.2174/0929867054637626

• Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy

  Journal of Analytical Atomic Spectrometry · 2004 · https://doi.org/10.1039/b309160k

• Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells

  Journal of Cancer Research and Clinical Oncology · 2004 · 10.1007/s00432-004-0617-0

• Recent Developments in the Field of Tumor-Inhibiting Metal Complexes

  Current Pharmaceutical Design · 2003 · 10.2174/1381612033454180

• Tumour-inhibiting platinum complexes—state of the art and future perspectives

  Reviews of physiology, biochemistry and pharmacology · 2003 · 10.1007/s10254-002-0001-x

• Gallium in cancer treatment

  Critical Reviews in Oncology/Hematology · 2002 · 10.1016/s1040-8428(01)00225-6

• The binding properties of two antitumor ruthenium(III) complexes to apotransferrin.

  Journal of Biological Chemistry · 1994 · 10.1016/s0021-9258(17)41984-3

• Metal complexes in cancer chemotherapy

  Medical Entomology and Zoology · 1993

Current projects

No projects listed.