Tom Misteli

Research interests

Publications

• The Self-Organizing Genome: Principles of Genome Architecture and Function

  Cell · 2020 · 10.1016/j.cell.2020.09.014

• Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization

  Cell · 2019 · 10.1016/j.cell.2019.01.020

• Repression of the Antioxidant NRF2 Pathway in Premature Aging

  Cell · 2016 · 10.1016/j.cell.2016.05.017

• Progeria: A Paradigm for Translational Medicine

  Cell · 2014 · https://doi.org/10.1016/j.cell.2013.12.028

• RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

  Nature · 2011 · 10.1038/nature10662

• The lamin protein family

  Genome biology · 2011 · 10.1186/gb-2011-12-5-222

• Epigenetics in Alternative Pre-mRNA Splicing

  Cell · 2011 · 10.1016/j.cell.2010.11.056

• Regulation of Alternative Splicing by Histone Modifications

  Science · 2010 · https://doi.org/10.1126/science.1184208

• Transcription Dynamics

  Molecular Cell · 2009 · 10.1016/j.molcel.2009.09.005

• Global Transcription in Pluripotent Embryonic Stem Cells

  Cell stem cell · 2008 · 10.1016/j.stem.2008.03.021

• Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

  Nature Cell Biology · 2008 · 10.1038/ncb1708

• Positional stability of single double-strand breaks in mammalian cells

  Nature Cell Biology · 2007 · 10.1038/ncb1591

• Beyond the Sequence: Cellular Organization of Genome Function

  Cell · 2007 · https://doi.org/10.1016/j.cell.2007.01.028

• Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression

  Cell · 2007 · 10.1016/j.cell.2006.11.040

• Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells

  Developmental Cell · 2006 · https://doi.org/10.1016/j.devcel.2005.10.017

• Chromatin in pluripotent embryonic stem cells and differentiation

  Nature Reviews Molecular Cell Biology · 2006 · 10.1038/nrm1938

• Lamin A-Dependent Nuclear Defects in Human Aging

  Science · 2006 · https://doi.org/10.1126/science.1127168

• Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

  Nature Medicine · 2005 · 10.1038/nm1204

• The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

  Proceedings of the National Academy of Sciences · 2003 · 10.1073/pnas.1433065100

• Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding

  Science · 2003 · 10.1126/science.1078572

• Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

  Nature · 2002 · https://doi.org/10.1038/nature00858

• Protein Dynamics: Implications for Nuclear Architecture and Gene Expression

  Science · 2001 · 10.1126/science.291.5505.843

• The concept of self-organization in cellular architecture

  The Journal of Cell Biology · 2001 · 10.1083/jcb.200108110

• Dynamic binding of histone H1 to chromatin in living cells

  Nature · 2000 · 10.1038/35048610

• High mobility of proteins in the mammalian cell nucleus

  Nature · 2000 · 10.1038/35007077

• The dynamics of a pre-mRNA splicing factor in living cells

  Nature · 1997 · 10.1038/387523a0

Current projects

No projects listed.