Clifton E. Barry

Research interests

Publications

• Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3767

• Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis

  New England Journal of Medicine · 2017 · https://doi.org/10.1056/nejmoa1614915

• Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3195

• Tuberculosis

  The Lancet · 2015 · 10.1016/s0140-6736(15)00151-8

• The association between sterilizing activity and drug distribution into tuberculosis lesions

  Nature Medicine · 2015 · 10.1038/nm.3937

• Extensive Drug Resistance Acquired During Treatment of Multidrug-Resistant Tuberculosis

  Clinical Infectious Diseases · 2014 · https://doi.org/10.1093/cid/ciu572

• Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

  Nature · 2014 · 10.1038/nature13489

• SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

  Antimicrobial Agents and Chemotherapy · 2012 · 10.1128/aac.05708-11

• Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis

  New England Journal of Medicine · 2012 · 10.1056/nejmoa1201964

• Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

  Science · 2011 · 10.1126/science.1208813

• Tuberculosis: What We Don’t Know Can, and Does, Hurt Us

  Science · 2010 · 10.1126/science.1184784

• Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB

  CHEST Journal · 2009 · 10.1378/chest.09-0903

• Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

  Science · 2009 · 10.1126/science.1167498

• The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

  Nature Reviews Microbiology · 2009 · https://doi.org/10.1038/nrmicro2236

• Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

  Infection and Immunity · 2008 · 10.1128/iai.01515-07

• PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

  Science · 2008 · 10.1126/science.1164571

• Elemental Analysis of Mycobacterium avium -, Mycobacterium tuberculosis -, and Mycobacterium smegmatis -Containing Phagosomes Indicates Pathogen-Induced Microenvironments within the Host Cell’s Endosomal System

  The Journal of Immunology · 2005 · 10.4049/jimmunol.174.3.1491

• The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of Metabolism

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m406796200

• A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response

  Nature · 2004 · 10.1038/nature02837

• Tuberculosis — metabolism and respiration in the absence of growth

  Nature Reviews Microbiology · 2004 · 10.1038/nrmicro1065

• DnaE2 Polymerase Contributes to In Vivo Survival and the Emergence of Drug Resistance in Mycobacterium tuberculosis

  Cell · 2003 · 10.1016/s0092-8674(03)00270-8

• Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β

  Proceedings of the National Academy of Sciences · 2001 · 10.1073/pnas.091096998

• A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

  Nature · 2000 · https://doi.org/10.1038/35016103

• The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.97.3.1252

• Mycolic acids: structure, biosynthesis and physiological functions

  Progress in Lipid Research · 1998 · 10.1016/s0163-7827(98)00008-3

• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

  Nature · 1998 · https://doi.org/10.1038/31159

• Compensatory ahp C Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis

  Science · 1996 · 10.1126/science.272.5268.1641

Current projects

No projects listed.