Xin Wei Wang

Research interests

Publications

• The Lancet Commission on addressing the global hepatocellular carcinoma burden: comprehensive strategies from prevention to treatment

  The Lancet · 2025 · https://doi.org/10.1016/s0140-6736(25)01042-6

• Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma

  Journal of Hepatology · 2021 · https://doi.org/10.1016/j.jhep.2021.06.028

• Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

  Cancer Cell · 2019 · https://doi.org/10.1016/j.ccell.2019.08.007

• Necroptosis microenvironment directs lineage commitment in liver cancer

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0519-y

• Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

  Science · 2018 · https://doi.org/10.1126/science.aan5931

• Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.05.009

• Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.09.003

• Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma

  Hepatology · 2012 · https://doi.org/10.1002/hep.25890

• Sixty-five gene-based risk score classifier predicts overall survival in hepatocellular carcinoma

  Hepatology · 2011 · https://doi.org/10.1002/hep.24813

• SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

  Cancer Cell · 2011 · https://doi.org/10.1016/j.ccr.2011.09.004

• A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients

  Cancer Research · 2010 · https://doi.org/10.1158/0008-5472.can-10-2607

• MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer

  New England Journal of Medicine · 2009 · https://doi.org/10.1056/nejmoa0901282

• EpCAM and α-Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma

  Cancer Research · 2008 · https://doi.org/10.1158/0008-5472.can-07-6013

• EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

  Gastroenterology · 2008 · https://doi.org/10.1053/j.gastro.2008.12.004

• Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

  Cancer Cell · 2008 · https://doi.org/10.1016/j.ccr.2008.09.001

• Identification of metastasis-related microRNAs in hepatocellular carcinoma

  Hepatology · 2008 · https://doi.org/10.1002/hep.22160

• TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer

  Oncogene · 2007 · https://doi.org/10.1038/sj.onc.1210279

• Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment

  Cancer Cell · 2006 · https://doi.org/10.1016/j.ccr.2006.06.016

• Predicting hepatitis B virus–positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning

  Nature Medicine · 2003 · https://doi.org/10.1038/nm843

• Functional Interaction of p53 and BLM DNA Helicase in Apoptosis

  Journal of Biological Chemistry · 2001 · https://doi.org/10.1074/jbc.m103298200

• GADD45 induction of a G 2 /M cell cycle checkpoint

  Proceedings of the National Academy of Sciences · 1999 · https://doi.org/10.1073/pnas.96.7.3706

• Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

  Molecular Cell · 1999 · https://doi.org/10.1016/s1097-2765(00)80466-9

• p53-Mediated apoptosis is attenuated in Werner syndrome cells

  Genes & Development · 1999 · https://doi.org/10.1101/gad.13.11.1355

• p53 modulation of TFIIH–associated nucleotide excision repair activity

  Nature Genetics · 1995 · https://doi.org/10.1038/ng0695-188

• Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

  Proceedings of the National Academy of Sciences · 1994 · https://doi.org/10.1073/pnas.91.6.2230

Current projects

No projects listed.