Mariana J. Kaplan

Research interests

Publications

• Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases

  Nature reviews. Immunology · 2022 · 10.1038/s41577-022-00787-0

• Neutrophil phenotypes and functions in cancer: A consensus statement

  The Journal of Experimental Medicine · 2022 · 10.1084/jem.20220011

• Patients with COVID-19: in the dark-NETs of neutrophils

  Cell Death and Differentiation · 2021 · 10.1038/s41418-021-00805-z

• Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa2026834

• Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

  Proceedings of the National Academy of Sciences · 2019 · 10.1073/pnas.1908576116

• VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

  Science · 2019 · 10.1126/science.aav4011

• To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

  Cell Death and Differentiation · 2019 · 10.1038/s41418-018-0261-x

• Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis

  Science Immunology · 2017 · 10.1126/sciimmunol.aag3358

• 18 F‐Fluorodeoxyglucose–Positron Emission Tomography As an Imaging Biomarker in a Prospective, Longitudinal Cohort of Patients With Large Vessel Vasculitis

  Arthritis & Rheumatology · 2017 · 10.1002/art.40379

• Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

  Nature Medicine · 2016 · https://doi.org/10.1038/nm.4027

• The role of neutrophils and NETosis in autoimmune and renal diseases

  Nature Reviews Nephrology · 2016 · 10.1038/nrneph.2016.71

• Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

  Annals of the Rheumatic Diseases · 2014 · 10.1136/annrheumdis-2013-204837

• Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

  Circulation Research · 2014 · 10.1161/circresaha.114.303312

• Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice

  Annals of the Rheumatic Diseases · 2014 · 10.1136/annrheumdis-2014-205365

• Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

  The Journal of Immunology · 2013 · 10.4049/jimmunol.1302005

• Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

  Journal of Clinical Investigation · 2013 · 10.1172/jci67390

• NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

  Science Translational Medicine · 2013 · https://doi.org/10.1126/scitranslmed.3005580

• Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity

  Seminars in Immunopathology · 2013 · 10.1007/s00281-013-0375-7

• Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

  The Journal of Immunology · 2012 · https://doi.org/10.4049/jimmunol.1201719

• Neutrophil Extracellular Trap–Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

  The Journal of Immunology · 2012 · 10.4049/jimmunol.1202388

• Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

  The Journal of Immunology · 2011 · https://doi.org/10.4049/jimmunol.1100450

• Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

  The Journal of Immunology · 2011 · 10.4049/jimmunol.1100123

• Neutrophils in the pathogenesis and manifestations of SLE

  Nature Reviews Rheumatology · 2011 · 10.1038/nrrheum.2011.132

• A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

  The Journal of Immunology · 2010 · 10.4049/jimmunol.0902199

• Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus

  Arthritis & Rheumatism · 2002 · 10.1002/art.10234

Current projects

No projects listed.