Harry L. Malech

Research interests

Publications

• Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1

  New England Journal of Medicine · 2019 · 10.1056/nejmoa1815408

• Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

  Nature Neuroscience · 2017 · 10.1038/nn.4534

• Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

  Nature Medicine · 2016 · https://doi.org/10.1038/nm.4027

• Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency

  Science Translational Medicine · 2016 · 10.1126/scitranslmed.aad8856

• Common Severe Infections in Chronic Granulomatous Disease

  Clinical Infectious Diseases · 2014 · 10.1093/cid/ciu1154

• Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease

  New England Journal of Medicine · 2010 · 10.1056/nejmoa1007097

• STAT3 Mutations in the Hyper-IgE Syndrome

  New England Journal of Medicine · 2007 · https://doi.org/10.1056/nejmoa073687

• Gastrointestinal Involvement in Chronic Granulomatous Disease

  PEDIATRICS · 2004 · 10.1542/peds.114.2.462

• Itraconazole to Prevent Fungal Infections in Chronic Granulomatous Disease

  New England Journal of Medicine · 2003 · 10.1056/nejmoa021931

• Treatment of Chronic Granulomatous Disease with Nonmyeloablative Conditioning and a T-Cell–Depleted Hematopoietic Allograft

  New England Journal of Medicine · 2001 · 10.1056/nejm200103223441203

• Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease

  Medicine · 2000 · https://doi.org/10.1097/00005792-200005000-00004

• Chronic Granulomatous Disease: Report on a National Registry of 368 Patients

  Medicine · 2000 · https://doi.org/10.1097/00005792-200005000-00003

• The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators

  Blood · 2000 · 10.1182/blood.v95.10.3223

• Hyper-IgE Syndrome with Recurrent Infections — An Autosomal Dominant Multisystem Disorder

  New England Journal of Medicine · 1999 · 10.1056/nejm199903043400904

• Genetic Linkage of Hyper-IgE Syndrome to Chromosome 4

  The American Journal of Human Genetics · 1999 · 10.1086/302547

• Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease

  Proceedings of the National Academy of Sciences · 1997 · 10.1073/pnas.94.22.12133

• Flow cytometric analysis of the granulocyte respiratory burst: a comparison study of fluorescent probes

  Journal of Immunological Methods · 1995 · 10.1016/0022-1759(94)00247-t

• Cytochrome b 558 : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

  Science · 1992 · 10.1126/science.1318579

• Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 c-src

  Science · 1990 · 10.1126/science.1692159

• Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

  Science · 1989 · 10.1126/science.2547247

• Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

  Science · 1988 · 10.1126/science.2848319

• Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

  Journal of Biological Chemistry · 1987 · 10.1016/s0021-9258(18)47849-0

• Neutrophils in Human Diseases

  New England Journal of Medicine · 1987 · https://doi.org/10.1056/nejm198709103171107

• Fungal infection in chronic granulomatous disease

  The American Journal of Medicine · 1981 · 10.1016/0002-9343(81)90259-x

• Structural analysis of human neutrophil migration: Centriole, microtubule, and microfilament orientation and function during chemotaxis

  The Journal of Cell Biology · 1977 · 10.1083/jcb.75.3.666

Current projects

No projects listed.