Andrew Singleton

Research interests

Publications

• A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research

  The Lancet Neurology · 2024 · https://doi.org/10.1016/s1474-4422(23)00405-2

• Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

  Nature Genetics · 2023 · https://doi.org/10.1038/s41588-023-01584-8

• Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-26280-1

• Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets

  JAMA Neurology · 2021 · https://doi.org/10.1001/jamaneurol.2020.5257

• The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort

  Annals of Clinical and Translational Neurology · 2018 · https://doi.org/10.1002/acn3.644

• Diagnosis and management of dementia with Lewy bodies

  Neurology · 2017 · https://doi.org/10.1212/wnl.0000000000004058

• Genetic and phenotypic characterization of complex hereditary spastic paraplegia

  Brain · 2016 · https://doi.org/10.1093/brain/aww111

• The transcriptional landscape of age in human peripheral blood

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms9570

• DNA Methylation of Lipid-Related Genes Affects Blood Lipid Levels

  Circulation Cardiovascular Genetics · 2015 · https://doi.org/10.1161/circgenetics.114.000804

• Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers

  Brain · 2014 · https://doi.org/10.1093/brain/awu179

• Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.3043

• A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies

  JAMA Neurology · 2013 · https://doi.org/10.1001/jamaneurol.2013.1925

• Genome-wide association study of obsessive-compulsive disorder

  Molecular Psychiatry · 2012 · https://doi.org/10.1038/mp.2012.85

• The genetics and neuropathology of Parkinson’s disease

  Acta Neuropathologica · 2012 · https://doi.org/10.1007/s00401-012-1013-5

• A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

  Neuron · 2011 · 10.1016/j.neuron.2011.09.010

• Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

  Nature Genetics · 2011 · 10.1038/ng.859

• The Parkinson Progression Marker Initiative (PPMI)

  Progress in Neurobiology · 2011 · 10.1016/j.pneurobio.2011.09.005

• Early‐onset L‐dopa‐responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations

  Movement Disorders · 2010 · https://doi.org/10.1002/mds.23221

• Genome-wide association study reveals genetic risk underlying Parkinson's disease

  Nature Genetics · 2009 · 10.1038/ng.487

• SNCA variants are associated with increased risk for multiple system atrophy

  Annals of Neurology · 2009 · https://doi.org/10.1002/ana.21685

• Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

  Brain · 2009 · 10.1093/brain/awp044

• Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

  New England Journal of Medicine · 2009 · 10.1056/nejmoa0901281

• Genotype-Imputation Accuracy across Worldwide Human Populations

  The American Journal of Human Genetics · 2009 · https://doi.org/10.1016/j.ajhg.2009.01.013

• Genotype, haplotype and copy-number variation in worldwide human populations

  Nature · 2008 · https://doi.org/10.1038/nature06742

• Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

  The American Journal of Human Genetics · 2008 · https://doi.org/10.1016/j.ajhg.2008.09.012

• Characterization of PLA2G6 as a locus for dystonia‐parkinsonism

  Annals of Neurology · 2008 · https://doi.org/10.1002/ana.21415

• Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11

  Nature Genetics · 2007 · https://doi.org/10.1038/ng.2007.43

• Deletion at ITPR1 Underlies Ataxia in Mice and Spinocerebellar Ataxia 15 in Humans

  PLoS Genetics · 2007 · https://doi.org/10.1371/journal.pgen.0030108

• Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes

  Journal of Neurology Neurosurgery & Psychiatry · 2006 · https://doi.org/10.1136/jnnp.2006.109553

• Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

  Neurobiology of Disease · 2006 · 10.1016/j.nbd.2006.04.001

• A common LRRK2 mutation in idiopathic Parkinson's disease

  The Lancet · 2005 · 10.1016/s0140-6736(05)17830-1

• Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

  Neuron · 2004 · 10.1016/j.neuron.2004.10.023

Current projects

No projects listed.