Michael R. Erdos

Research interests

Publications

• In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice

  Nature · 2021 · 10.1038/s41586-020-03086-7

• New genetic loci link adipose and insulin biology to body fat distribution

  Nature · 2015 · https://doi.org/10.1038/nature14132

• Super-enhancers delineate disease-associated regulatory nodes in T cells

  Nature · 2015 · 10.1038/nature14154

• Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1317023110

• Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

  Diabetes · 2013 · 10.2337/db13-0949

• A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2274

• Correlated alterations in genome organization, histone methylation, and DNA–lamin A/C interactions in Hutchinson-Gilford progeria syndrome

  Genome Research · 2012 · 10.1101/gr.138032.112

• Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

  Science Translational Medicine · 2011 · 10.1126/scitranslmed.3002346

• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.609

• Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.521

• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.520

• Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

  Arteriosclerosis Thrombosis and Vascular Biology · 2010 · 10.1161/atvbaha.110.209460

• Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

  Nature Genetics · 2008 · 10.1038/ng.120

• Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

  Nature Genetics · 2008 · 10.1038/ng.288

• Variants in MTNR1B influence fasting glucose levels

  Nature Genetics · 2008 · 10.1038/ng.290

• Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

  Nature Genetics · 2008 · 10.1038/ng.287

• A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

  Science · 2007 · 10.1126/science.1142382

• Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0602569103

• Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

  Proceedings of the National Academy of Sciences · 2005 · 10.1073/pnas.0506001102

• Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome

  Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0402943101

• Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

  Nature · 2003 · 10.1038/nature01629

• BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

  Science · 1999 · 10.1126/science.284.5418.1354

• Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription

  Cell · 1999 · 10.1016/s0092-8674(00)80967-8

• Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

  Nature Genetics · 1994 · 10.1038/ng1294-387

• Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

  Nature · 1994 · 10.1038/369330a0

Current projects

No projects listed.