Narisu Narisu

Research interests

Publications

• SARS-CoV-2 infection induces beta cell transdifferentiation

  Cell Metabolism · 2021 · 10.1016/j.cmet.2021.05.015

• In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice

  Nature · 2021 · 10.1038/s41586-020-03086-7

• Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

  Nature Communications · 2020 · 10.1038/s41467-020-18581-8

• Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle

  Proceedings of the National Academy of Sciences · 2019 · 10.1073/pnas.1814263116

• Single-cell ATAC-Seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures

  Molecular Metabolism · 2019 · 10.1016/j.molmet.2019.12.006

• Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

  The American Journal of Human Genetics · 2017 · 10.1016/j.ajhg.2017.01.027

• Genetic regulatory signatures underlying islet gene expression and type 2 diabetes

  Proceedings of the National Academy of Sciences · 2017 · 10.1073/pnas.1621192114

• Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

  Nature Genetics · 2016 · 10.1038/ng.3654

• The genetic regulatory signature of type 2 diabetes in human skeletal muscle

  Nature Communications · 2016 · 10.1038/ncomms11764

• Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

  Diabetes · 2013 · 10.2337/db13-0949

• Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1317023110

• Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

  Diabetes · 2011 · 10.2337/db11-0415

• Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.686

• Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.521

• Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.685

• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.609

• Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

  Diabetes · 2010 · 10.2337/db09-1568

• Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

  PLoS Genetics · 2009 · 10.1371/journal.pgen.1000508

• Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

  Human Molecular Genetics · 2009 · 10.1093/hmg/ddp522

• Newly identified loci that influence lipid concentrations and risk of coronary artery disease

  Nature Genetics · 2008 · https://doi.org/10.1038/ng.76

• Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

  Nature Genetics · 2008 · 10.1038/ng.120

• A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

  Science · 2007 · 10.1126/science.1142382

• Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample

  Diabetes · 2006 · 10.2337/db06-0341

• Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes

  Diabetes · 2004 · 10.2337/diabetes.53.4.1141

Current projects

No projects listed.