Eliezer Masliah

Research interests

Publications

• Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment

  Proceedings of the National Academy of Sciences · 2023 · https://doi.org/10.1073/pnas.2214634120

• Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00785-3

• A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

  Acta Neuropathologica · 2019 · https://doi.org/10.1007/s00401-019-02026-8

• NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease

  Alzheimer s & Dementia · 2018 · https://doi.org/10.1016/j.jalz.2018.02.018

• Diagnosis and management of dementia with Lewy bodies

  Neurology · 2017 · https://doi.org/10.1212/wnl.0000000000004058

• Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

  The Lancet Neurology · 2017 · https://doi.org/10.1016/s1474-4422(17)30400-3

• Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease

  Proceedings of the National Academy of Sciences · 2017 · https://doi.org/10.1073/pnas.1617259114

• Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium

  Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2017 · https://doi.org/10.17615/8xge-z676

• Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

  Autophagy · 2017 · https://doi.org/10.1080/15548627.2017.1395992

• PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

  Acta Neuropathologica · 2015 · https://doi.org/10.1007/s00401-015-1407-2

• Primary age-related tauopathy (PART): a common pathology associated with human aging

  Acta Neuropathologica · 2014 · https://doi.org/10.1007/s00401-014-1349-0

• TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

  Acta Neuropathologica · 2014 · https://doi.org/10.1007/s00401-013-1239-x

• The many faces of α-synuclein: from structure and toxicity to therapeutic target

  Nature reviews. Neuroscience · 2012 · https://doi.org/10.1038/nrn3406

• Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

  Cell · 2012 · 10.1016/j.cell.2012.02.046

• Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

  Human Molecular Genetics · 2012 · https://doi.org/10.1093/hmg/dds161

• National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

  Alzheimer s & Dementia · 2012 · 10.1016/j.jalz.2011.10.007

• Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

  Journal of Neuropathology & Experimental Neurology · 2012 · https://doi.org/10.1097/nen.0b013e31825018f7

• National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

  Acta Neuropathologica · 2011 · 10.1007/s00401-011-0910-3

• Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

  Nature Genetics · 2011 · 10.1038/ng.801

• In vivo demonstration that α-synuclein oligomers are toxic

  Proceedings of the National Academy of Sciences · 2011 · 10.1073/pnas.1100976108

• Neuropathological Alterations in Alzheimer Disease

  Cold Spring Harbor Perspectives in Medicine · 2011 · https://doi.org/10.1101/cshperspect.a006189

• Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

  Nature Genetics · 2010 · 10.1038/ng.536

• Polyamine pathway contributes to the pathogenesis of Parkinson disease

  Proceedings of the National Academy of Sciences · 2010 · https://doi.org/10.1073/pnas.1011751107

• Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network

  Neuron · 2010 · https://doi.org/10.1016/j.neuron.2010.10.020

• Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein

  Proceedings of the National Academy of Sciences · 2009 · 10.1073/pnas.0903691106

• Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

  Science · 2006 · https://doi.org/10.1126/science.1134108

• Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease

  Science · 2005 · 10.1126/science.1105681

• α-Synuclein is phosphorylated in synucleinopathy lesions

  Nature Cell Biology · 2002 · 10.1038/ncb748

• High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

  Journal of Neuroscience · 2000 · 10.1523/jneurosci.20-11-04050.2000

• Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

  Science · 2000 · 10.1126/science.287.5456.1265

• Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

  Nature · 1995 · 10.1038/373523a0

• The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

  Neuron · 1995 · 10.1016/0896-6273(95)90302-x

• Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

  Proceedings of the National Academy of Sciences · 1993 · 10.1073/pnas.90.23.11282

• Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

  Annals of Neurology · 1991 · https://doi.org/10.1002/ana.410300410

Current projects

No projects listed.