Alain Townsend

Research interests

Publications

• SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

  Cell · 2022 · https://doi.org/10.1016/j.cell.2021.12.046

• A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

  Nature Communications · 2021 · 10.1038/s41467-020-20654-7

• Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-25167-5

• The antigenic anatomy of SARS-CoV-2 receptor binding domain

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.02.032

• Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

  Nature Structural & Molecular Biology · 2020 · 10.1038/s41594-020-0469-6

• Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

  Cell Host & Microbe · 2020 · 10.1016/j.chom.2020.06.010

• Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

  Nature Structural & Molecular Biology · 2020 · 10.1038/s41594-020-0480-y

• Autophagy is a critical regulator of memory CD8+ T cell formation

  eLife · 2014 · 10.7554/elife.03706

• Hepcidin regulation by innate immune and infectious stimuli

  Blood · 2011 · 10.1182/blood-2011-04-351957

• Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

  Journal of Clinical Investigation · 2008 · 10.1172/jci32460

• A peptide encoded by human gene MAGE‐3 and presented by HLA‐A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE‐3

  European Journal of Immunology · 1994 · 10.1002/eji.1830241218

• Molecular analysis of the association of HLA-B53 and resistance to severe malaria

  Nature · 1992 · https://doi.org/10.1038/360434a0

• Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

  Nature · 1992 · https://doi.org/10.1038/355641a0

• Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer

  Nature · 1992 · 10.1038/355644a0

• Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter

  Nature · 1991 · 10.1038/354528a0

• Presentation of viral antigen controlled by a gene in the major histocompatibility complex

  Nature · 1990 · 10.1038/345449a0

• Assembly of MHC class I molecules analyzed in vitro

  Cell · 1990 · 10.1016/0092-8674(90)90366-m

• Empty MHC class I molecules come out in the cold

  Nature · 1990 · https://doi.org/10.1038/346476a0

• Association of class I major histocompatibility heavy and light chains induced by viral peptides

  Nature · 1989 · https://doi.org/10.1038/340443a0

• Antigen Recognition by Class I-Restricted T Lymphocytes

  Annual Review of Immunology · 1989 · https://doi.org/10.1146/annurev.iy.07.040189.003125

• HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

  Nature · 1988 · 10.1038/336484a0

• Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

  The Journal of Experimental Medicine · 1988 · 10.1084/jem.168.4.1211

• Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2

  Nature · 1987 · 10.1038/326881a0

• The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

  Cell · 1986 · https://doi.org/10.1016/0092-8674(86)90019-x

• Cytotoxic T cells recognize fragments of the influenza nucleoprotein

  Cell · 1985 · 10.1016/0092-8674(85)90103-5

• Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells

  Cell · 1984 · 10.1016/0092-8674(84)90187-9

Current projects

No projects listed.