Bart De Strooper

Research interests

Publications

• The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

  Nature Reviews Drug Discovery · 2022 · 10.1038/s41573-022-00391-w

• Microglia states and nomenclature: A field at its crossroads

  Neuron · 2022 · https://doi.org/10.1016/j.neuron.2022.10.020

• Reactive astrocyte nomenclature, definitions, and future directions

  Nature Neuroscience · 2021 · https://doi.org/10.1038/s41593-020-00783-4

• Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.06.038

• The β-Secretase BACE1 in Alzheimer’s Disease

  Biological Psychiatry · 2020 · https://doi.org/10.1016/j.biopsych.2020.02.001

• The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

  Cell Reports · 2019 · https://doi.org/10.1016/j.celrep.2019.03.099

• Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

  Cell · 2018 · 10.1016/j.cell.2018.07.048

• APP mouse models for Alzheimer's disease preclinical studies

  The EMBO Journal · 2017 · 10.15252/embj.201797397

• The Cellular Phase of Alzheimer’s Disease

  Cell · 2016 · 10.1016/j.cell.2015.12.056

• Alzheimer's disease

  The Lancet · 2016 · 10.1016/s0140-6736(15)01124-1

• Melanoma addiction to the long non-coding RNA SAMMSON

  Nature · 2016 · 10.1038/nature17161

• The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

  Nature Neuroscience · 2012 · 10.1038/nn.3028

• The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

  Nature Reviews Drug Discovery · 2011 · 10.1038/nrd3505

• The secretases: enzymes with therapeutic potential in Alzheimer disease

  Nature Reviews Neurology · 2010 · 10.1038/nrneurol.2009.218

• Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression

  Proceedings of the National Academy of Sciences · 2008 · 10.1073/pnas.0710263105

• Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

  Science · 2006 · 10.1126/science.1132341

• OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

  Cell · 2006 · 10.1016/j.cell.2006.06.025

• Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

  Cell · 2006 · 10.1016/j.cell.2006.06.021

• Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

  Cell · 2006 · 10.1016/j.cell.2006.06.059

• ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation

  Proceedings of the National Academy of Sciences · 2005 · 10.1073/pnas.0500918102

• Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

  Neuron · 2003 · 10.1016/s0896-6273(03)00205-8

• Proteolytic processing and cell biological functions of the amyloid precursor protein

  Journal of Cell Science · 2000 · 10.1242/jcs.113.11.1857

• A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

  Nature · 1999 · 10.1038/19083

• Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

  Proceedings of the National Academy of Sciences · 1998 · 10.1073/pnas.95.11.6460

• Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

  Nature · 1998 · 10.1038/34910

Current projects

No projects listed.